Sentences with phrase «prior therapy»

The Phase 2, double - blind trial enrolled 142 patients with advanced melanoma who had not received prior therapy.

The patients were all high risk and had received many prior therapies.

The median number of prior therapies for these patients was three; all the patients had been treated previously with at least one other EGFR TKI therapy, and most patients receiving chemotherapy as well.

The trial included 63 patients with histologically confirmed marginal zone lymphoma who had received one or more prior therapy including at least one CD20 monoclonal antibody.

Moreover, experimental cancer agents are usually tested in patients who have already received several prior therapies, which blunt the immune system, Schlom remarks.

Prof Soria will say: «Re-sensitisation to TKI can not account for the majority of these responses, since most patients had come off TKI as their immediate prior therapy.»

A class of oral specialty drugs, tyrosine kinase inhibitors (TKIs), has revolutionized the treatment of CML, largely transforming it into a chronic condition and enabling many patients to have a near - normal lifespan, particularly when compared to a median survival of less than three years with prior therapies.

The median age of the patients is 61 and all are heavily pretreated — the median number of prior therapies was 6.3.

We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.

New data released earlier this week from another pivotal phase III clinical trial (study CA184 - 024) show the antibody also extends survival in patients with metastatic melanoma who have not received prior therapy.

«For patients who have not responded to prior therapies, this drug now provides a very real chance to shrink their tumors and the hope of a lasting response to treatment.»

The phase II clinical study included results from 51 patients enrolled at 10 centers around the world with progressive, radioactive iodine - refractory (RAI) papillary thyroid cancer and a BRAF mutation who were no longer responding to prior therapies.

The appropriate comparator therapy specified by the Federal Joint Committee (G - BA) was antineoplastic drug treatment at the physician's discretion under consideration of the respective approval status of the drugs currently used and of the prior therapies.

Responses to the combination therapy did not correlated with prior chemotherapy, the number of prior rituximab doses, or duration of response to prior therapy.

Ibrutinib is also approved to treat chronic lymphocytic leukemia / small lymphocytic lymphoma, including patients with 17p deletion, mantle cell lymphoma after at least one prior therapy, and patients with Waldenstrom macroglobulinemia.

Even though more than half of the patients had received prior therapy, the appraisal was less positive for individual therapy (cf the Applicability of the blended intervention section).

It will also increase your overall happiness and may lower your divorce rate by 31 % in comparison to couples who go into marriage without any prior therapy.