Sentences with phrase «promoter sequences»
Promoter sequences are specific regions of DNA that control the initiation of gene expression. They act like a "start" button, telling the cell when and where to begin reading the instructions (or genes) encoded in DNA. Promoter sequences play a crucial role in determining which genes are turned on or off in different cells or at different times, ultimately influencing various biological processes. Full definition
The shortest genomic region capable of rescuing forward and backward locomotion defects in unc - 7 mutants encompassed the coding region of unc - 7 and 1 kb of promoter sequence upstream of exon 2 (unc - 7 min; Figure 3B).
neuraldevelopment.biomedcentral.com
The Punc - 7S promoter sequences in intron 3 were eliminated by substituting this region with unc - 7 cDNA sequence from exons 2 — 6 (unc -7-2cDNA6; Figure 3E).
But the benefits of this technology for discerning the circuits of the mind go much deeper, because the virus that carries the photoreceptor genes can also carry promoter sequences that express their payload only in neurons with the appropriate molecular address.
The immunoprecipitated chromatin by anti — IRF - 9 antibody was analyzed by PCR using primers specific for RIG - G promoter sequences (+11 to − 288).
Together these studies suggest that Punc - 7S drives expression of UNC - 7S in a subset of neurons (including AVA and AVB, but not motor neurons) that can effect rescue of forward locomotion, and promoter sequences upstream of exon 2 drive additional expression of UNC - 7S in motor neurons or possibly other neurons required to fully rescue all unc - 7 locomotory defects.
It has the growth hormone of the Chinook salmon and the promoter sequence (a molecular switch that turns on growth - hormone production) of the ocean pout, a fish that grows year - round rather than just during warm - weather months.
In addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, MTFP1.
Promoter reporter analysis showed that unphosphorylated STAT6 enhanced COX - 2 promoter activities, and EMSA experiments also documented the binding of STAT6 to the COX - 2 promoter sequence.
By comparing the promoter sequences of expressed with non-expressed OR and VR genes and pseudogenes, it may now be possible to identify key genomic motifs that control receptor choice.
A shorter version of unc - 7 min lacked promoter sequences upstream of exon 2 (unc - 7S:: gfp; Figure 3C) and rescued forward but not backward locomotion, suggesting that promoter sequences in intron 3 (Punc - 7S; Figure 3C) drive a subset of UNC - 7S expression sufficient to rescue only forward movement.
Cosmid F56B12 includes presumptive upstream promoter sequences and ends within intron 3.