Sentences with phrase «protein kinase»

Calcium and DAG activate protein kinase C, which, in turn, activates the MAPK and PI3K / AKT pathways which allow the upregulation of cell proliferation and anti-apoptosis signals [42].

Enhancement of the glutamate response by cAMP - dependent protein kinase in hippocampal neurons

Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

The megakaryocyte / platelet - specific enhancer of the a2b1 integrin gene: Two tandem AP1 sites and the mitogen activated protein kinase signaling cascade.

The enhanced hiPS - HEP cells respond to insulin with phosphorylation of protein kinase B - α (Akt), even at low insulin concentrations, and the genes involved in glycogen metabolism, gluconeogenesis, and insulin signaling are expressed at similar levels as in hphep cells.

Furthermore, the research revealed the part of the EMSY protein is changed by an enzyme called protein kinase A.

20) and several chemical drugs including mitogen - activated protein kinase inhibitor and histone deacetylase inhibitor (21, 22).

P significantly increased hypothalamic cAMP levels and cAMP - dependent protein kinase activity.

Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with protein kinase A, cytoskeletal elements, the heterotrimeric protein complex RAVE and the glycolytic enzyme aldolase.

Role of the p38 Mitogen - Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide — Dependent Cellular Responses

Emk is a serine / threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics.

Receptor interacting protein kinase 1 (RIPK1) has important kinase - dependent and kinase - independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell...

Because of the lack of existing therapies, the KU team chose to examine a member of a family of protein kinase enzymes.

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

AMP - activated Protein Kinase mediates mitochondrial fission in response to energetic stress

No. 5,817,479, entitled Human Kinase Homologs, claims 44 ESTs which are fragments of genes encoding protein kinases.

Now, Dong et al. have investigated the consequences of Dab2 downregulation in a new STEM CELLS Translational Medicine study, demonstrating a novel role for calcium / calmodulin - dependent protein kinase kinase - 1 (CAMKK1) in the modulation of MSC secreted factors and a potential exciting means to enhance MSC - based cardiac repair [2].

M156 normally inhibits a rabbit's virus - defense factor called protein kinase R, or PKR.

So we looked to see whether middle T also had an associated protein kinase activity, and we were delighted to find that it did.»

Unlike the ESTs of the NIH application, these EST sequences were identified by their specific similarity to known protein kinase cDNAs.

The roles of Toll - like receptor 9, MyD88, and DNA - dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.

The human protein kinase HIPK2 phosphorylates and downregulates the methyl - binding transcription factor ZBTB4.

Berberine reduces insulin resistance through protein kinase C - dependent up - regulation of insulin receptor expression..

GS is covalently modified by phosphorylation at nine serine residues by several protein kinases.

Resistance to ethanol intoxication in mice lacking protein kinase C delta Doo - Sup Choi - University of California, San Francisco, USA

Dr. Soumen Paul has worked with medicinal chemists to design analogues of a compound capable of inhibiting protein kinase c lambda / iota.

In the study, the team used KnIT to mine the medical literature up to 2003 when only half of the 33 phosphorylating protein kinases had been discovered.

The new regulatory mechanism involves protein kinase SIK3, which controls the activity of other proteins by phosphorylating them.

Dietary sugars, such as glucose, are sensed intracellularly by a regulatory system, which includes transcription factor Mondo - Mlx and protein kinase SIK3.

She QB, Bode AM, Ma WY, Chen NY and Dong Z. Resveratrol - induced activation of p53 and apoptosis is mediated by extracellular - signal - regulated protein kinases and p38 kinase.

Drewry and his fellow scientists aim to ensure the therapeutic potential of as many protein kinases as possible will be uncovered.

The over-activated protein kinase p38 MAPK damages the wiring of the communication network within the brain.

The target is a stress - related protein kinase, p38alpha MAPK.

Here we identify protein kinase N1 (PKN1) as a novel key...

In the study analyzing its effects on arthritis, 15d - PGJ2 mediated shear - induced chondrocyte apoptosis via protein kinase A (PKA)- dependent regulation of PLK1.