Sentences with word «recombination»

Cancer Network: What are the ways to test for this deficiency of homologous recombination in patients with ovarian cancer?

This approach allows to obtain models in shorter timelines and with reduced costs compared to gene targeting by homologous recombination in ES cells.

Rochester scientists discover gene controlling genetic recombination rates 23.04.2018 University of Rochester

There are several features unique to meiosis, most importantly the pairing and genetic recombination between homologous chromosomes.

Intron size correlates positively with recombination rate in Caenorhabditis elegans.

First, the packaging system is split into two plasmids: one encoding Rev and one encoding Gag and Pol, increasing the number of recombination events necessary to create a replication - competent virus.

Homologous meiotic recombination occurs in most sexually reproducing organisms, yet its evolutionary advantages are elusive.

He completed his postdoctoral studies in gene targeting and DNA recombination at Massachusetts Institute of Technology (MIT).

What else do we know about understanding how homologous recombination deficiency as a marker can guide clinical practice?

Because the chromosomes of each parent undergo genetic recombination during meiosis, each gamete, and thus each zygote, will have a unique genetic blueprint encoded in its DNA.

As alluded to above, the Cre recombinase catalyzes the site specific recombination event between two loxP sites, which can be located either on the same or on separate pieces of DNA.

There are basically two types of lines, those produced by collisions between the atoms or ions and the electrons in the surrounding gas, which are called collision lines, and which are very bright for elements such as oxygen, nitrogen and neon, and lines which are produced when ions capture free electrons, which are called recombination lines, and which are bright only for those gases with the highest abundances in the interstellar medium: hydrogen and helium.

«A Directional Strategy for Monitoring Cre - Mediated Recombination at the Cellular Level in the Mouse.»

Antibodies are generated through recombination of a fixed set of germline immunoglobulin segments, called V genes, with other germline immunoglobulin segments.

Detection of Ionized Gas: The 140 - foot telescope made the first unambiguous detection of recombination lines at radio frequencies, which are powerful tools for studying ionized gas in the Milky Way Galaxy.

The FLP recombinase recognizes FRT sites and initiates site directed gene recombination between those sites.

For the first time, researchers at the Stowers Institute have mapped where recombination occurs across the whole genome of the fruit fly Drosophila melanogaster after a single round of meiosis.

BRCA2 regulates DMC1 - mediated recombination through the BRC repeats Juan S. Martinez, Catharina von Nicolai, Taeho Kim, Åsa Ehlén, Alexander V. Mazin, Stephen C. Kowalczykowski and Aura Carreira PNAS, doi: 10.1073 / pnas.1601691113

Since emerging adenovirus strains such as HAdV - 14 and HAdV - D22 / H8 (otherwise known as HAdV - D53) are known to arise from recombination events among related ancestral strains [32], [33], we performed bootscanning analysis to look for such events in TMAdV.

In 2005, deCODE identified a genetic variant that correlates with higher recombination rate, the first genetic variant ever demonstrated to be under positive evolutionary selection in human populations in real time.

These variant lox sites undergo recombination with other sites of the same type, but are not cross-compatible.

Finally, we found that genes in regions of the genome with a low recombination frequency tend to have a higher ratio of non-synonymous to synonymous substitutions, likely due to the accumulation of slightly deleterious non-synonymous substitutions.

To date, to create murine models, researchers use methods combining the Cre - Lox recombination system and the use of embryonic stem cells, but these processes are long and tedious, and it takes about 3 - 4 years to create a new mouse model.

But the team found the opposite: the passenger pigeon's strong social structure favored beneficial mutations for living at high densities, driving selection throughout the species and decreasing genetic diversity in large sections of the genome where recombination seldom occurs.

The team was using a well - known Cre - lox genetic recombination system to get mouse neurons to express green, yellow, orange, and red fluorescent proteins.

Researchers have previously made LEDs with the right energy gap to emit in the mid-infrared band, but these have fallen prey to an effect called Auger recombination — in which electrons and holes recombine without producing light.

«There are gene - rich regions that are in low recombination regions, which is critically important for plant breeding,» Close said.

The authors confirm a previous finding that older mothers have more recombination events in the transmission of their genome to their offspring, while the father's age has no such effect.

For a given wind speed, including hydrogen recombination results in a larger offset angle, and thus more redistribution of heat.

Moreover, as transposons quickly accumulate the probability of deletions through non-allelic homologous recombination also increases, counteracting their initial impact on genome growth [11, 12].

One of them states that homologous meiotic recombination increases the efficiency of natural selection by alleviating interference between linked sites, thereby facilitating adaptive evolution and the purging of deleterious mutations [7]--[11].

CCHa2 - RKO51 - 2 was generated by gene targeting using homologous recombination [22][23].

He has established the basic conceptual framework of class switch recombination starting from discovery of DNA deletion (1978) and S regions (1980), followed by elucidation of the whole mouse immunoglobulin heavy - chain locus.

By sequencing the entire genome of 30 African honeybees, the research team has been able to study recombination at a level of detail not previously possible.

It is the first time such recombination has been seen between vaccine viruses in the wild.

Fig. 1: Spectrum showing the line of hydrogen recombination observed with ALMA looking toward the massive protostar G345.4938 +01.4677.

However, the 52mer specifically interacted with the site and also effectively inhibited the Hin - mediated recombination reaction.

Yeast studies had suggested that Mus81 was critical for a specific stage in cell division that's essential for chromosome recombination during reproduction.

«With ongoing studies of the homologous recombination pathway and its impact on cancer development, we may identify additional genes that, when mutated, allow for either improved response to specific treatments or conversely, portend more aggressive tumor biology, and this could greatly inform development of new cancer therapies,» Heeke explains.

The certified external quantum efficiency of 96 % at 300nm wavelength demonstrates that the increased surface recombination problem no longer exists and for the first time the black silicon is not limiting the final energy conversion efficiency.