Sentences with phrase «signal transduction pathways»

Anticancer activities of several anthelminthics attracted considerable interest, especially their capacity to target signal transduction pathways of CSCs / TICs of several tumor types.

At the cellular level, it signals through a cell surface receptor kinase - mediated signal transduction pathway instead of through the nuclear receptor family of transcription factors.

We describe assembly and function of a complete synthetic signal transduction pathway in plants that links input from computationally re-designed PBPs to a visual response.

Citation: Antunes MS, Morey KJ, Smith JJ, Albrecht KD, Bowen TA, Zdunek JK, et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway.

Computational biology; use of control and information theory to study signal transduction pathways.

«The mammary epithelial cell secretome and its regulation by signal transduction pathways.»

We do a lot of detailed signal transduction pathway mapping, Kinase assays and binding assays.

My postdoctoral work involved signal transduction pathways that regulate chemotaxis.

Thus, the organism may use signal transduction pathways to modulate stress response and life - span.

A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.

Growth of osteosarcoma cells was inhibited by this drug by targeting of multiple signal transduction pathways [41].

It is known that both hypoxia and consecutive hypoxia / reoxygenation can exert a variety of effects on tumor cell biology, including activation of pro-survival signal transduction pathways, aberrant genetic and epigenetic alterations, and increased tumor angiogenesis.

The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.

The Herlyn lab is defining signal transduction pathways that are constitutively activated in melanoma and squamous cell cancer cells through autocrine and paracrine growth factors and genetic alterations.

His laboratory is currently focused on characterizing signal transduction pathway abnormalities in prostate cancer, with an eye toward translational implications.

Recent studies have shown that ALA has a positive impact on insulin action (via the insulin signal transduction pathway) and muscle glucose transport, especially in people whose insulin function is suboptimal, i.e. have developed insulin resistance.

While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.

Murat completed his PhD at NCSU focusing on systems biology of growth factor - mediated signal transduction pathways.

Our synthetic signal transduction pathway is able to functionally link input from the computationally re-designed receptors to a plant response system, producing a prototype detector plant.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.

The project will first focus on the sensors of the cell wall integrity (CWI) signal transduction pathway and their relation to the control of the spatial and temporal organization of protein complexes and regulatory components during yeast cytokinesis.

The actin cytoskeleton mediates these responses, but the signal transduction pathway leading to chloroplast movement and the mechanism of chloroplast motility is not entirely understood.

The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.

(C) Absence of signal dependent nuclear translocation of a mutated PhoB - GFP in the synthetic signal transduction pathway.

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

We are investigating the signal transduction pathways that lead to activation of the GAIT system, the mechanisms by which two of the proteins escape their parent complexes, and the in vivo function of the pathway.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

Our finding that Gasp constitutively associated with Grb2 is quite intriguing and provides some possible links to hypothesize its function in positive selection, because Grb2 is an important adaptor for Sos in the TCR - mediated signal transduction pathway.