Sentences with phrase «solid tumors»
The phrase "solid tumors" refers to abnormal growths or masses of cells that form a lump in the body, typically in organs or tissues. These tumors are not liquid-filled and differ from cancers like leukemia, which affect the blood or bone marrow. Instead, solid tumors closely stick together, making them easier to evaluate and treat. Examples of solid tumors include breast cancer, lung cancer, and brain tumors. Full definition
Although breast cancer was the initial focus and featured in the study published online today, the team has also conducted experiments with other types of solid tumors, with similar results.
sciencedaily.com
Part of that is because cancer cells in solid tumors appear to have learned how to «hide» better.
There is currently a PD - 1 antibody on the market that blocks T cell exhaustion in patients with solid tumors, like lung cancer and melanoma.
Vitamin D protects against many cancers; the protective effect is strongest for solid tumor cancers like breast cancer, ovarian cancer, and colon cancer.
The drug was generally well tolerated, and several of the 26 patients with advanced solid tumors experienced stable disease for greater than six months.
The authors hope that this work may provide the basis for the start of a clinical trial for ovarian cancer, and indeed, for other solid tumors.
By freely sharing unique tools with no obligation to collaborate, we aim to promote fundamental research and new treatments for pediatric patients with poorly understood and difficult - to - treat solid tumors.
Her research interests are focused on the cellular and molecular events critical to T - cell mediated immunity for the clinical implementation of T cell therapy against solid tumors.
His current research focuses on the identification and validation of therapeutic targets in pediatric solid tumors and rare cancers.
By injecting a combination of two immune boosters into solid tumors in mice, scientists were able to eliminate all traces of the cancer in the body.
Single - cell DNA solid tumor profiling enables high resolution of the genomic diversity in a variety of tumor types.
By observing glucose metabolism activity it may therefore be possible to identify solid tumors or very aggressively growing tumor areas.
But the drugs have been limited by cancer cells ability to development resistance, as well as the inhibitors inability to fight solid tumors effectively.
The best care for solid tumors requires a team approach, with pediatric specialists from multiple disciplines coming together under one coordinated setting to provide the best chances for a cure.
Brain tumors are the most common form of solid tumors among children under the age of 15.
But scientists say there are many barriers before they think they can get the treatments to work in other types of solid tumors.
Continue reading to learn about our current clinical trials for children with solid tumors.
Trials in solid tumors are expected to be introduced in the fall 2017.
The other two trials study drugs to treat solid tumors.
«This is a landmark paper in several respects,» said Philip Kantoff, MD, leader of the Lank Center for Genitourinary Oncology and chief of Solid Tumor Oncology at Dana - Farber, a senior author of the study.
The multikinase angiogenesis inhibitor pazopanib was well tolerated and exhibited some responses in pediatric patients with soft - tissue sarcomas and other refractory solid tumors in a phase I trial.
Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.
He further showed that PD - L1 is highly expressed on many solid tumors such as breast and lung, as well as some hematologic malignancies, and allows these tumors to resist immune attack.
ICELL8 can isolate up to 1,800 single cells, ranging from 5 μm — 100 μm in size on a single chip, including cells from solid tumors, brain cells, pulmonary airway cells, and multiple cell lines.
«Surgery is the main treatment option for patients with most solid tumors, but recurrence and metastasis remain significant problems,» says study senior author Michael Goldberg, PhD, assistant professor at Dana - Farber and Harvard Medical School.
The trial «Niraparib Plus Carboplatin in Patients with Homologous Recombination Deficient Advanced Solid Tumor Malignancies» is not yet recruiting patients for enrollment.
Caris, under the guidance of Baker, provided the tissue and ran the molecular profiling on solid tumor samples collected from across the United States.
Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.
Dr. Matthias Stephan has developed a way to make cell - based immunotherapy as effective against solid tumors as it has been against blood cancers such as leukemia.
«There are certainly challenges to overcome for clinical application of this kind of immunotherapy, but the newly published data are an important milestone in immunotherapy targeting solid tumors that have eluded other treatments.»
«The prolongation in survival seen in the prostate cancer patients participating in Dr. Sweeney's study is very impressive, dramatically longer than the typical 2 - 6 month prolongation typically observed in successful studies of other metastatic adult solid tumors,» said Bruce E. Johnson, MD, Dana - Farber's chief clinical research officer.
The study included 116 St. Jude patients with central nervous system tumors, which are the most commonly diagnosed solid tumor in childhood.
Alexander Drilon, MD, Assistant Attending Physician in the Developmental Therapeutics Clinic and the Thoracic Oncology Service, will report results from the international phase I STARTRK - 1 and STARTRK - 2 clinical trials, which assessed entrectinib as a treatment for patients with advanced solid tumors harboring gene rearrangements and of which he is principal investigator at MSK.
«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of how cancer spreads through the body to the point that other scientists have confirmed the process in other solid tumor cell types such as pancreatic cancer.»
Right now, that's where most of the big successes have come from, but that could one day include solid tumors and maybe even autoimmune diseases like Type 1 diabetes, Epstein said.
Resolve the genomic diversity in a variety of tumors by targeting hotspots across 50 oncogenes and tumor suppressor genes relevant in a range of different solid tumors with SNV and indel mutation detection.
[15, 16] Further studies have shown that blockade of the PD1 - PD - L1 pathway augments anti-tumor activity provides therapy for multiple solid tumors, including RCC.
The abstract title was: CTC 11 - 001: Phase I study of Carfilzomib (C) + Irinotecan (I) in relapsed solid tumors.
Checkpoint inhibitors for various solid tumors cost about $ 150,000 a year, and a personalized treatment called chimeric antigen receptor — T cell therapy tops out at $ 475,000.
Despite the promise shown by antibody - based therapies, the large molecular size of antibodies limits their ability to efficiently penetrate solid tumors and precludes efficient crossing of the blood - brain - barrier into the central nervous system (CNS).
«This development has the potential to enable earlier detection of solid tumors through a simple blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while in the lab of senior author Jay Shendure, M.D., Ph.D., a professor in genome sciences at the University of Washington.
P: We found discodermolide [a drug from Discodermia, a sponge found in the Caribbean, the Bahamas, and the Gulf of Mexico], and it's gone through phase I clinical trials for treatment of solid tumors such as ovarian, pancreatic, breast, colon, or lung cancers.
Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.
Around 5 - 10 % of patients with solid tumors who are treated with chemotherapy, radiation or autologous stem cell transplantation develop treatment - related MDS or AML.
As part of the Pediatric Solid Tumor group at DFCI and Children's Hospital, we help organize laboratory and clinical cross talk.