Sentences with phrase «stem cell factor»

They used a virus to deliver four stem cell factors into skin cells.

These new findings uncover the first direct connection between stem cell factors and the control of genome architecture, and explains why stem cell heterochromatin is normally in an open and uncompacted form.

Unexpectedly, this pathway assigns new roles for several well - known stem cell factors.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

These hair precursor, or progenitor, cells then produce a protein called stem cell factor (SCF) that the researchers showed is essential for hair pigmentation.

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

They made adult fibroblastic mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the fibroblasts to express four key embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.

After five days, EBs were dissociated and seeded in serum - free medium supplemented with 100ng / ml murine stem cell factor (R & D), 10 − 6M dexamethasone (Sigma - Aldrich), 40 ng / ml IGF - 1 (Promega), 2 ng / ml IL3, 5 ng / ml IL - 6, and 10 ng / ml mflt - 3L.

For EBI2 transduction of BM - derived cells, BM cells were harvested 4 days after 5 - flurouracil (Sigma) injection and cultured in the presence of recombinant IL - 3, IL - 6, and mouse stem cell factor (SCF)(100 ng / ml; Peprotech; Rocky Hill, NJ).

Dr Peter Rugg - Gunn, senior author on the research paper and research group leader at the Babraham Institute explained: «This unanticipated connection between stem cell factors and heterochromatin organisation is important because it tells us about how stem cells work.

«Deletion of a stem cell factor promotes traumatic brain injury recovery in mice.»

The research showed that the stem cell factors, Nanog and Sall1, bind to heterochromatin and help to maintain this portion of the genome in an open form.

In animal studies, the virus used to introduce the stem cell factors sometimes causes cancers.

At the same time, the protein Vascular Endothelial Growth Factor (VEGF) stimulates blood supply for the damaged tissue, Fibroblast Growth Factor - 2 (FGF - 2) stimulates the damaged cells to grow and reproduce themselves, Transforming Growth Factor - beta (TGF - beta) stimulates cartilage to grow, and Stem Cell Factor (SCF) stimulates your native inactive stem cells to become activated and assist in the repair of the damaged tissue.