Sentences with phrase «stem cell fate»

Particularly, he is interested in the analysis of stem cell fate decisions and of individual stem cell clone dynamics.

The concentration of each regulator would ultimately influence this network and neural stem cell fate with the options of self - renewal, differentiation or tumor development.

The relative simplicity of the process means biologists have a much greater chance of reliably influencing stem cell fate.

The team lead by Prof. Verdon Taylor was able to demonstrate for the first time a cell - intrinsic mechanism regulating stem cell fate.

According to Ihor Lemischka, director of the Black Family Stem Cell Institute at Mount Sinai in New York City, this is one of the first computational models of stem cell fate decisions.

The finding, that the simple mechanical properties of a surface can play a big role in helping stem cells decide what to be, promises to help scientists better define the experimental conditions to direct stem cell fate.

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

«Our research results about the function of Drosha challenge the way we used to think about how stem cell fate is controlled,» says cell biologist Taylor.

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

Further, he is focusing on lipid metabolism (lipolysis) on stem cell fate.

Her group is particularly interested in the cellular and molecular mechanisms which control lung epithelial stem cell fate decisions.

Found that muscle - specific histone methyltransferases and microRNAs regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem cell fate decisions.

Professor Sten Eirik Jacobsen is head of the research program which is focused on identifying molecular mechanisms governing stem cell fate decisions, and lineage development within the hematopoietic system.

Recent work by Fleming researchers identifies a Wnt - regulated long non-coding RNA that controls intestinal stem cell fate and carcinogenesis.

Metabolic control of primed human pluripotent stem cell fate and function by the miR - 200c - SIRT2 axis.

This illustrates how biophysical cues determine stem cell fate and spatial patterning.

In an earlier study, Jones had shown that the hub cells secrete the self - renewal factor upd, which signals neighboring stem cells to maintain stem cell fate, making hub cells an essential component of the stem cell niche.

«It's amazing that a single molecule can direct stem cell fate.

«Sniffing out stem cell fates in the nose: Using single - cell RNA sequencing and clever statistical analysis to track stem cells as they mature.»

«What decides neural stem cell fate?

We are broadly interested in understanding the mechanisms that regulate stem cell fate and self - renewal, and how these mechanisms are dysregulated in cancer.

His research interests include the mechano - regulation of stem cell fate, in particular chondrogenic differentiation.

Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.

«This finding not only identifies a new mechanism that regulates totipotent stem cells, but also reveals the importance of non-coding RNAs in stem cell fate.»

Hypoxia - mediated regulation of stem cell fate.

«Our method provides new design criteria for materials used in regenerative medicine, and the work also provides more support to the general concept that stem cell fate can be regulated by mechanical cues,» adds Mooney.