Sentences with phrase «survival factor»

The tumor - cell survival factors uncovered by this study might one day be targeted with drugs to further diminish people's risk of metastasis.

These factors include chemokine (C - X-C motif) ligand 12 (CXCL12), a chemokine produced by bone marrow mesenchymal cells that functions as a chemoattractant and survival factor for cells bearing the chemokine (C - X-C motif) receptor 4 (CXCR4), and insulin - like growth factor 1 (IGF - 1), a factor that is stored in the bone matrix and released during osteolysis (28).

Whitehead Institute researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast, colon, and lung cancers.

Whitehead Institute scientists report that patients whose estrogen receptor (ER)- positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes — including increased mortality.

AKT is a well - known survival factor that phosphorylates and activates oncoprotein HDM2 (also known as murine double minute 2 (MDM2), HDM2 in humans), and in turn, HDM2 induces degradation of p53 [8, 9].

Researchers found that male ostracods, also known as seed shrimp, evolved heavily in terms of their appearance to the point that they missed on other survival factors.

Takano T, Azuma N, Satoh M, Toda A, Hashida Y, Satoh R, Hohdatsu T. 2009 Neutrophil survival factors (TNF - alpha, GM - CSF, and G - CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions.

STAT5 belongs to a family of transcription factors that regulate cytokine - induced gene expression and is constitutively activated in several human cancers including breast cancer, where it promotes the expression of genes encoding cell survival factors (44).

To design the study, he combined these two elements with the long - time focus of Horvath's lab on STAT3, which has been implicated in cancer in general, as both a causative agent and a survival factor.

To accomplish these duties, inflammatory cells produce an array of biochemicals that can benefit tumor growth, notably growth factors, survival factors, and matrix - modification enzymes.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

SASP factors range from inflammatory and immune - modulatory cytokines to chemokines as well as growth factors, shed cell surface molecules, survival factors and extracellular matrix remodeling enzymes.

Thus, upon activation by ActD, AKT becomes an inducer of p53 tumor suppression instead of being a survival factor, as consistently shown in human embryonic kidney cell lines (293 and 293T), human hepatoma cell line (HepG2), and mouse hepatoma cell line (Hepa - 1c1c7).

PI3K - AKT signaling has been reported to promote the activation of the oncoprotein HDM2 and to downregulate the p53 tumor suppressor [28], and therefore AKT is defined as a survival factor.

Financial, safety, and survival factors are important to consider while looking for stocks on the TSX index The TSX is the abbreviated name for the Toronto Stock Exchange.