Sentences with phrase «to target tumors»
For instance, imaging could be used in new cancer treatments in which the patient's own immune system is employed to target tumor cells.
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Alone or in conjunction with surgery and chemotherapy, radiation therapy is useful for its ability to specifically target tumors.
We focus on providing treatments that effectively target tumors while minimizing radiation exposure to nearby healthy tissues.
Your animal will need to be under anesthesia during the procedure to prevent movement and to accurately target the tumor site.
This allows the circuit to target tumors more accurately than existing therapies, as it requires two cancer - specific signals to be present before it will respond.
Other radiation treatments that require targeting the tumor from an external source, which exposes healthy tissues and limits how high a dose can be safely delivered.
Traditional treatments typically target tumors but leave the stem cells behind, making them more aggressive and allowing them to rebuild the tumor rapidly.
A relatively new treatment approach, SRT allows veterinary surgeons to precisely target a tumor with a stronger doses of radiation without damaging the surrounding healthy tissue.
In conclusion, the data presented in this manuscript lay the groundwork for a novel delivery technology that, in addition to its use for molecular imaging applications such as noninvasive PET, could also be exploited for targeted tumor therapies.
By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients.
Nonetheless, low - dose computed tomography screens may change diagnostic prospects in the future, and recently developed therapies targeting tumors harboring mutations in EGFR or ALK receptors are showing promise.
Because the toxin does not target the tumor cells themselves but rather the host - derived blood vessel cells, the strategy could be efficacious for a wide range of tumor types, the NIH team notes.
Cancer treatments often target tumors by cutting off blood vessels and other nutrient supply routes, so Monje and others are interested to learn whether it may be possible to target nerves via analogous therapies or by simply blocking secreted neural growth factors.
Intensity - modulated radiation therapy (IMRT), which targets tumors better than conventional radiation
Entinostat Therapy Plays Favorable Role in Targeting the Tumor Microenvironment to Enhance Immune Checkpoint Therapy
Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic «payload» and promoter tumor growth inhibitionsy
The ultimate goal is to be able to inject therapeutic bacteria into a patient's body — for example, as probiotics to help treat diseases of the gut or as targeted tumor treatments — and then use ultrasound machines to hit the engineered bacteria with sound waves to generate images that reveal the locations of the microbes.
That came up in an immunotherapy discussion that I had at Davos with Carl Jeun and Jose Bisalga, when you're working on immunotherapy and you have specific targeted tumors how, you know, is it still from a regulatory standpoint, is it still moral to wait and try to do other when you have a specific tumor that's specific to a particular person.
Studying mice implanted with human cervical cancer cells, the investigators wiped out many of the animals» tumors with a combination of radiation and three drugs that target tumor metabolism.
Cancer immunotherapy can be viewed as «The Breakthrough of 2013», switching cancer treatment from targeting the tumor to targeting the immune system.
For example, knowing that IL - 37 helps to create overall immune system sensitivity could allow researchers to manipulate IL - 37 levels to sensitize the immune system to recognize and target tumor tissue, or desensitize the immune system in auto - immune conditions like rheumatoid arthritis in which the immune system acts over-aggressively toward healthy tissue.
Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.
Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.
«The idea is to mobilize an immune response that will target the tumor very broadly, hitting a variety of markers including some that would be found only on that particular tumor,» Tanyi said.
In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.
«This compound could potentially enhance the positive parts of TNF - alpha by only targeting tumor cells or inflammatory cells.»
Importantly, it's secretion from normal cells can be induced by activating p53 so that Par - 4 enters circulation, thereby potentially targeting tumor cells at distant sites.
Genetically modified Salmonella bacteria target tumors and make the immune system extra aggressive toward cancer cells.
In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.
The project builds on Dr. Slamon's previous work partially funded by CIRM to develop a drug that targets tumor initiating cells with UCLA's Dr. Zev Wainberg, assistant professor of hematology / oncology and Dr. Tak Mak, director, Campbell Family Institute of the University Health Network in Toronto, Canada.
Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.
Meanwhile, the consistently denim - clad Kamen meets a pair of researchers in Montreal who are building another type of medical mini-robot to travel through the bloodstream targeting tumors with precision chemotherapy.
Treatments that rely on modified polioviruses to target tumors such as glioblastomas are already in clinical trials in the United States, and there's a modified herpesvirus approved by the U.S. Food and Drug Administration for treating melanoma.
The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.
After the vaccination, twenty - seven percent of T - cells in the blood of the mice in the study targeted the tumors.
«Titan targets tumors: Large computational gains made in laser - driven radiation therapy of cancer.»
Typically, the capsules are attracted to a specific protein that the cancer cells produce, preferentially targeting tumors while leaving healthy cells untouched.
Using this approach, immune cells are taken from a patient's bloodstream, reprogrammed to recognize and attack a specific protein found in cancer cells, then reintroduced into the patient's system, where they get to work destroying targeted tumor cells.
Many of us believe that a number of anti-cancer therapies fail to succeed because we are still unable to target tumor stem cells.
This immuno - oncology technology is further being leveraged to target tumor self - antigens or shared neoantigens.
IMRT targets tumors better than conventional radiation therapy.
One of our lead product candidates, CMB305, was developed under this approach and targets tumors expressing the NY - ESO - 1 antigen.
243/2: 15 Towards personalized cellular adoptive immunotherapy targeting tumor specific neo-antigens in microsatellite unstable colorectal cancers.
174/5: 45 A novel (epi) genotype - specific and histotype - targeted tumor surveillance protocol in Beckwith - Wiedemann Syndrome based on cancer data meta - analysis.
Investigators from the Massachusetts General Hospital (MGH) Vaccine and Immunotherapy Center report in the Journal of Hematology & Oncology that a protein engineered to combine a molecule targeting a tumor - cell - surface antigen with another protein that stimulates several immune functions prolonged survival in animal models of both tumors.
Through the EPR effect, nanoparticles larger than 8 nm (between 8 - 100 nm) can passively target tumors by freely pass through large pores and achieve higher intratumoral accumulation.»