Because of the ease with which the CRISPR / Cas9 system can be applied, it has quickly become a robust tool for generating accurate genetic disease models in the laboratory and for
identifying novel therapeutic targets in the clinic.
Research released today highlights advances in the use of CRISPR - Cas9 and human induced pluripotent stem cell technologies to
identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction.
As an investigator in TGen's Pharmaceutical Genomics Division, Dr. Azorsa applied siRNA screening to
identify novel therapeutic targets in cancer as well as functionally relevant gene targets that modulate drug response.
Mapping the epigenome will allow Vijay and his team to zoom in on those genes with the greatest likelihood to contribute to disease, and the cell types in which they act, and therefore will
help identify novel therapeutic targets.
«We have
identified a novel therapeutic target for the treatment of severe influenza that is effective under conditions where known antiviral drugs fail to protect from death.»
Further exploration of the TCA cycle, using metabolomics, may
identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
The SMA Foundation has invested over $ 85M in basic and translational research aimed at understanding the biology of SMA pathogenesis,
identifying novel therapeutic targets, and developing research tools to systematically and efficiently determine the efficacy of potential treatments.
We are looking at the role of complement proteins in inflammatory diseases such as atherosclerosis, to
identify novel therapeutic targets.
Two new precision medicine tests that look beyond cancer genes to
identify novel therapeutic targets have just received New York State Department of Health approval and are now available to both oncologists and cancer researchers for use at the front lines of patient care.
His research focuses on studying the role that SUMOylation (a protein modification pathway) plays in Huntington's disease, with hopes of targeting the SUMO pathway to
identify novel therapeutic targets.
Our goal is to
identify novel therapeutic targets and participate in both preclinical and clinical studies of new drugs and other interventions.
Two new precision medicine tests that look beyond cancer genes to
identify novel therapeutic targets are now available to both oncologists and cancer researchers.