Sentences with phrase «to regulate gene expression»

Both were known to be active in regulating gene expression in the liver, kidney, and intestine.

A short stretch of DNA that regulates gene expression by acting as a landing platform for regulatory proteins, e.g. transcription factors.

It protects cells against free radical damage and helps regulate gene expression and cell signaling.

It's also important for regulating gene expression, and this compound has been found to play a role in activating more than 200 different genes.

The results of this study contrast sharply with the generally accepted view of the key roles that these epigenetic marks play in regulating gene expression.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

PHYSIOLOGY OR MEDICINE: Andrew Z. Fire of the Stanford University School of Medicine and Craig C. Mello of the University of Massachusetts Medical School, for their 1998 discovery of RNA interference, which regulates gene expression and helps defend cells against viruses.

Enzymes that chemically modify DNA, known as DNA methyltranferases, play critical roles in regulating gene expression during development, but their role in cancer formation is less clear.

It is a crucial network in the nucleus, providing mechanical support to the nucleus and also regulating gene expression by making some areas of the genome less or more available to be transcribed into messenger RNA.

«We are only scratching the surface of what could be critical as yet unrecognized mechanisms by which cells regulate gene expression» says co-principal investigator and ICREA research professor at CNAG - CRG, Marc A. Martí - Renom.

«New insights into mechanisms regulating gene expression in embryonic stem cells.»

The structural descriptions of human PRC2 with its natural partners in the cell lend important insight into the mechanism by which the PRC2 complex regulates gene expression.

YAP can be found in the cytoplasm but also the nucleus of a cell, and when it is in the nucleus, YAP regulates gene expression.

Epigenetics regulates gene expression in a reversible manner by chemically modifying DNA and histone proteins, which prevent permanent mutations or alterations within the gene themselves.

They correspond to DNA's major and minor grooves, where proteins interact with the DNA to carry out biological processes such as regulating gene expression.

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

«These findings underscore the significance of Gcn5 - regulated gene expression coupled with the metabolic enzyme alpha - KGDH in tumor cell proliferation and formation.»

«Although the medical applications utilizing light regulated gene expression are in the distant future, the first applications will be probably found among life science basic research areas which are in the need of accurate control of gene function» Dr. Rossi says.

Their findings, described in and featured on the cover of the current issue of Genes and Development, reveal that many of these lncRNAs in the lung regulate gene expression by opening and closing the DNA scaffolding on neighboring genes.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

On the DNA (deoxyribonucleic acid), the carrier of genetic information, scientists search for the grammar regulating gene expression, for instance.

MicroRNAs regulate gene expression and play key roles in many biological processes, such as cell death and metabolism.

The methylation of CpG sites regulates gene expressions.

ATRA regulates gene expression by activating the retinoic acid receptor.

MiRNAs are small endogenous noncoding RNAs which negatively regulate gene expression.

Regulation of a2 integrin gene espression during megakaryocte differentiation: A common theme of three necessary elements for megakaryocyte - specific, developmentally regulated gene expression.

We found a substantial increase in HIF - 1 protein during hypoxia, but this does not mean that HIF - 1 alone regulated gene expression.

The fundamental question he raises in his research is how lipid signaling regulates gene expression and how a changing extra - and intracellular lipid environment impacts the expression of the genome and contributes to changing cellular phenotypes.

Mechanisms of HDAC inhibitor regulated gene expression in cancer cells (Review).

The spatio - temporal organization of chromatin in the nucleus is emerging as a fundamental factor regulating gene expression.

He used the GM method to make discoveries about what regulates gene expression in GM plants, and about plant transposable DNA.

Typically, these marks are methyl groups that regulate gene expression so that one parent's allele is selectively expressed.

Transcription factors come together like words in a sentence to jointly regulate gene expression, Panne says.

Dr. Loftus» research is aimed at understanding how the human genome regulates gene expression, with a focus on how this controls the cellular processes governing mammalian development.

Dr. Loftus's research has gone on to detail how SOX10 and its downstream target gene MITF coordinately regulate gene expression profiles associated with melanocyte differentiation.

Chromatin's complex structure regulates gene expression, DNA repair and epigenetic inheritance.

While the role that DNA - binding proteins play in regulating gene expression at the transcriptional level is well studied, how RNA - binding proteins control gene expression at the post-transcriptional level is less clear.

The Wasserman laboratory focuses on the creation, evaluation and application of computational methods for the analysis of genome sequences, with international strength in the study of cis - regulatory elements regulating gene expression.

MicroRNAs and long non-coding RNAs (lncRNAs) have the capacity to regulate gene expression programs, and their differential expression within immune cells highlights their potential in defining immune cell identity and function.

Boron activates these cells through regulating gene expression.

As Dr. Swanson told us, «CtBP is a protein that senses the NADH / NAD ratio and regulates gene expression depending on this ratio.»

In the new study, Burrows and colleagues focused on the protein HIC1, or «Hypermethylated in cancer 1, «so named because it was first identified in cancer cells; however, it also helps regulate gene expression in normal cells.

Our findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.

This RNA does not code for a protein but is highly conserved by evolution, occurring in many species, and is involved in regulating gene expression during human development and cancer.

MAPKs (Mitogen - Activated Protein Kinases), which help the cell to respond to stress and inflammation, are vital in nature, but also regulate gene expression and survival.

He's focusing first on the role of microRNAs, which regulate gene expression, in pediatric brain cancers and some forms of leukemia.