Sentences with phrase «vaccinia virus»

Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS - CoV spike protein confers mucosal immunity in dromedary camels.

Late last week, FDA worked with the United States Attorney to ask a court to seize the components of a product that involved the use of vaccinia virus vaccine as part of a purported treatment for cancer that FDA believes created the potential for substantial risks to patients.

Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.

When other vaccinia viruses come knocking, long projections of another protein, actin, shoot out from the cell membrane, causing the virus to bounce off.

This image shows vaccinia viruses (the green dots) erupting from the surface of a human cell on long red actin plumes.

MVA is an alternative to the classic vaccinia virus, which can cause serious side effects.

The proteins work together to form a complex on the cell's surface that prevents other vaccinia virus particles from entering (a process called superinfection).

Using a light microscope, researchers at the Swiss Federal Institute of Technology in Zürich watched fluorescently tagged vaccinia virus — a more benign cousin of smallpox virus — migrate toward target cells.

The Pexa - Vec virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University in Philadelphia, who engineered the harmless vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity, in hopes of boosting the immune response to tumors.

While at UConn, he researched improvements to the system for generating recombinant vaccinia viruses in the laboratory of Dr. Paulo Verardi.

The vaccinia virus has been developed by the biotechnology company Jennerex — named after Edward Jenner, who in the 18th century discovered that a cowpox virus could inoculate against smallpox.

For their studies, Greber and his team with PhD students I - Hsuan Wang, Vardan Andriasyan and senior research scientist Dr. Maarit Suomalainen used cell cultures and human adenoviruses causing respiratory disease and conjunctivitis, herpes viruses and vaccinia virus, the latter in collaboration with Dr. Jason Mercer and his PhD student Samuel Kilcher from the ETH Zurich.

Geoffrey Smith and his team of virologists at Imperial College London were curious about the vaccinia virus, and set up a video microscope to watch how the virus spreads through cells.

When Smith watched the vaccinia virus infecting monkey liver cells, he thought that it was spreading far too quickly.

Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell - free conditions and in human cells, using a vaccinia virus vector.

When researchers infected these ERV - depleted cells with the vaccinia virus (which may be related to smallpox), they had a much weaker innate immune response than unedited normal cells, the team reports online today in Science.

Did you know, for example, that the vaccinia virus is a member of one of the largest and most complex of the vertebrate viruses?

That's what the vaccinia virus seems to be saying after it invades a cell and prevents its companions from following suit.

When the vaccinia virus was delivered in CIK cells, it was evenly distributed throughout the tumor (left).

Then, for the cargo, they chose the vaccinia virus.

Even though the Stanford team believes that the vaccinia viruses and the CIK cells are the best available right now, «it is possible that further investigation will produce improvements on this system,» says Contag.

On March 3, 2007, a two - year - old boy suffering from severe eczema and an unusual, widespread rash was transferred from St. Catherine's Hospital, in East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia virus.

To do this, a team led by Matthew Weitzman of the University of Pennsylvania crosslinked the host factors of infected human cells with the DNA of adenovirus, herpes simplex virus and vaccinia virus.

Treats herpes simplex viruses and vaccinia virus.

Temperature - sensitive mutants with lesions in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.