Sentences with phrase «vascular endothelial growth factor»

One class of drugs, called vascular endothelial growth factor inhibitors, for example, is designed to thwart the growth of abnormal blood vessels in the eye.

His study highlighted a role for vascular endothelial growth factor (VEGF) in N - methyl - D - aspartate (NMDA) receptor trafficking via the activation of long - term potentiation signaling pathways at the post-synaptic sites (De Rossi et al, 2016).

For this study, the researchers combined blood vessel growth protein vascular endothelial growth factor (VEGF) with PolyActive to form microspheres and tested the microspheres» effectiveness in pigs with induced heart attacks.

The use of targeting antibodies against vascular endothelial growth factor (VEGF), a protein that promotes tumor growth and spread, plus chemotherapy has prolonged disease free survival in several different tumor types in man.

These treatments involve regular injection of vascular endothelial growth factor inhibitors (anti-VEGF) into the eye.

And they incorporated into the gel a protein known as vascular endothelial growth factor (VEGF), which encourages the growth of blood vessels into the transplanted cells.

Further evidence of hypoxia is suggested by the increases in vascular endothelial growth factor (VEGF) expression in patients with diabetic retinopathy [3 — 5] and retinopathy of prematurity (ROP)[6], because VEGF is known to be a hypoxia - inducible gene [7,8].

This is very different mechanism of action than other agents that also effect angiogenesis by inhibiting vascular endothelial growth factor (VEGF) such as bevacizumab (Avastin; Genentech).

Previous efforts to treat ischemia by creating new blood vessels have focused on delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites.

High serum vascular endothelial growth factor level is an adverse prognostic factor for high - risk diffuse large B - cell lymphoma patients treated with dose - dense chemoimmunotherapy.

Bevacizumab (Avastin ®), which targets vascular endothelial growth factor (VEGF), is FDA - approved for the treatment of ovarian cancer.

Nintedanib, in addition to blocking vascular endothelial growth factor receptors (VEGFR) and platelet derived growth factor receptors (PDGFR), also acts on fibroblast growth factor receptors (FGFR), which makes it different to classical angiogenesis inhibitors.

Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF - A.

The newly developed porous films do not require an addition of costly growth factors, and they are capable of adsorbing vascular endothelial growth factors (VEGFs) that occur naturally in the body and taking them into the film materials.

Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.

Park, Y. S., Kim, N. H. & Jo, I. Hypoxia and vascular endothelial growth factor acutely up - regulate angiopoietin - 1 and Tie2 mRNA in bovine retinal pericytes.

Interestingly, PDGF - BB overexpression by modified hDPSCs enhanced the recruitment of hDPSCs both in vitro and in vivo via the activation of the phosphatidylinositol 3 kinase (PI3K) / Akt signaling pathway and, in combination with secreted vascular endothelial growth factor (VEGF), enhanced in vitro angiogenesis.

Vikas Gulati, MD Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska Funding provided by a grant from The Alcon Foundation Project: Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics

Lithium Upregulates Vascular Endothelial Growth Factor in Brain Endothelial Cells and Astrocytes

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

These leaking neutrophils end up causing the often resultant papules and pustules (p & p's) associated with rosacea, and are also responsible for stimulating Vascular Endothelial Growth Factor (VEGF) which promotes additional vascular growth, and thus the visible and non-visible excess blood vessels:

In this proposal we set out to utilize our canine - derived scFv phage display platform technology to isolate canine antibody fragments that bind and neutralize Vascular Endothelial Growth Factor (VEGF).

Plasma vascular endothelial growth factor (VEGF) concentrations in healthy dogs and dogs with hemangiosarcoma.

Vascular endothelial growth factor concentrations in body cavity effusions in dogs.

Specifically, they piece together a molecular signaling pathway by which a protein called vascular endothelial growth factor (Vegf) directs the activation of Delta - like 4 (Dll4), which is critical to artery formation.

Traditionally, scientists have thought that the protein Vascular Endothelial Growth Factor (VEGF) was responsible for guiding the angioblasts to the midline of the body for blood vessel formation.

Adults with advanced renal cell carcinoma after targeted therapy against vascular endothelial growth factor (VEGF)

A marker in bile known as vascular endothelial growth factor (VEGF) plays an important role in the growth of cancerous tumors according to new research presented at the 78th Annual Scientific Meeting of the American College of Gastroenterology.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

So Daniel Anderson at the Massachusetts Institute of Technology exposed human bone marrow stem cells to biodegradable nanoparticles carrying the human gene for vascular endothelial growth factor (VEGF), which attracts blood vessels to injury sites.

During his career, Dr. Aiello has received numerous awards, including sharing the 2014 Antonio Champalimaud Vision Award with Dr. George L. King at Joslin for their contributions toward the discovery of treatments inhibiting vascular endothelial growth factor (VEGF) for diabetic eye disease.

Cheeks and gums tend to heal more quickly than skin, without scarring, thanks to proteins in saliva like vascular endothelial growth factor that promote the formation of blood vessels.

High Serum Vascular Endothelial Growth Factor (VEGF) Level Is An Adverse Prognostic Factor In High Risk Diffuse Large B - Cell Lymphoma (DLBCL) Patients Treated with Dose - Dense Chemoimmunotherapy and Systemic CNS Prophylaxis.

The protein analyses revealed elevated levels of vascular endothelial growth factor, or VEGF, that correlated with moderate cases of the disease.

The cannabinoids inhibited the expression of several genes critical to angiogenesis known as the VEGF (vascular endothelial growth factor) pathway.

«Moreover, we found that vascular endothelial growth factor (VEGF) plays an important role in cell growth and survival.

This happens because the loss of blood flow in a vessel causes the local oxygen level to drop, which stimulates local production of vascular endothelial growth factor, or VEGF, a protein which in most tissues causes the growth of new blood vessels to repair damage.

Among dozens of mouse studies, he presented work led by Moderna Co-Founder Kenneth Chien, then at Harvard Medical School in Boston, showing that mice recovering from induced heart attacks survived longer and had stronger hearts when injected with mRNA encoding a protein that drives blood vessel formation — vascular endothelial growth factor (VEGF).

This protein binds to two growth factors — vascular endothelial growth factor (VEGF) and placental growth factor (PlGF)-- that promote the development of new blood vessels and the maintenance of the vascular system.

Vascular endothelial growth factor A (VEGF - A) is a protein associated with promotion of new blood vessel formation.

The findings are reported in «Vascular Endothelial Growth Factor, a Novel and Highly Accurate Pancreatic Fluid Biomarker for Serous Pancreatic Cysts» online in the Journal of the American College of Surgeons.

For the first time ever, the researchers have shown that NK cells produce a factor called VEGF - A (Vascular Endothelial Growth Factor A) that promotes tumor growth.

For example, leader cells secrete more VEGF (vascular endothelial growth factor) than followers do.

Linking the vascular endothelial growth factor (VEGF) genetic pathway with a specific disease characteristic among SLE patients represents an important step towards unravelling the genetic basis of different SLE clinical presentations.

Specifically, two factors were applied: the Vascular Endothelial Growth Factor (VEGF) and the Glial Cell - derived Neurotrophic Factor (GDNF).

They then turned to neurochemical studies, including lactate, glutamate and glutamine metabolism, effects on the hypothalamic - pituitary - adrenal (HPA) axis through cortisol secretion, and neurotrophins such as brain - derived neurotrophic factor (BDNF), insulin - like growth factor 1 (IGF - 1), and vascular endothelial growth factor (VEGF).