Sentences with word «vasopressor»

Cytokine release syndrome occurs when many cytokines get released into the serum upon CAR T - cell injection; patients can get high fevers and sometimes hypertension, and occasionally there is a need for mechanical ventilation or administration of vasopressors, but that is rare.

When the condition is not responsive to high - dose vasopressors like norepinephrine and vasopressin, it is associated with high mortality, with more than half of these patients dying within 30 days,» Dr. Khanna said.

Anthony C. Gordon, M.D., of Imperial College London, and colleagues randomly assigned patients who had septic shock requiring vasopressors despite fluid resuscitation within a maximum of 6 hours after the onset of shock to vasopressin and hydrocortisone (n = 101), vasopressin and placebo (n = 104), norepinephrine and hydrocortisone (n = 101), or norepinephrine and placebo (n = 103).

Norepinephrine is currently recommended as the first - line vasopressor (an agent that produces vasoconstriction and a rise in blood pressure) in septic shock; however, early vasopressin use has been proposed as an alternative.

CRH is a life - threatening condition with distributive shock who can not achieve target mean arterial pressure despite adequate fluid resuscitation and treatment with currently available vasopressors.

The study enrolled 321 patients — 163 treated with angiotensin II and 158 with placebo — who were experiencing vasodilatory shock and had received high doses of conventional vasopressors.

If fluids are not sufficient to support the blood pressure, vasopressors such as dopamine (1 — 3 mcg / kg / min constant - rate infusion1) can be included.

For numerous reasons, vasopressor therapy is often delayed until patients are very compromised, and morbidity or mortality are imminent.

Titrated multiple vasopressors, inotropes, and other cardiac supportive drips to maintain hemodynamic stability.

Management and titration of multiple intravenous medications, to include vasopressors, sedatives, and pain control devices

In ZUMA - 1, 12 % of the patients had a grade 3 or higher cytokine release syndrome and that is essentially a patient requiring mechanical ventilation or needing treatment with a high - dose vasopressor.

In veterinary medicine, the use of vasopressors and inotropic drugs is preferred before risking injury with high volumes of crystalloids and HES.11

Norepinephrine is recommended as the first - line vasopressor (a drug that constricts [narrows] blood vessels, increasing blood pressure) for treatment of hypotension (abnormally low blood pressure) due to septic shock.

Treatment may include aggressive fluid therapy with monitoring urinary output, vasopressors, pain control (aggressive pain control may be warranted), antioxidants such as N acetylcysteine, diphenhydramine, anti-seizure medications, oxygen, gastroprotectants and transfusions.

Session Info: Vasopressors are an integral part of early goal - directed therapy, but can be an intimidating step for many clinicians.

Provides direct care for surgical, neurosurgical, and medical critical patients, including hemodynamic monitoring, titration of sedation and vasopressors, as well as care for ventilator patients and neurosurgical patients, including ICP monitoring.

For patients with suspected infection within the ICU, the SOFA score had predictive validity (AUROC = 0.74; 95 % CI, 0.73 - 0.76) superior to that of this model (AUROC = 0.66; 95 % CI, 0.64 - 0.68), likely reflecting the modifying effects of interventions (eg, vasopressors, sedative agents, mechanical ventilation).