Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation. (science.sciencemag.org)
Additionally, P - eIF2α dependent translation of mRNAs regulated by upstream open reading frames (uORFs) contributes to the molecular signature of stemness. (inmg.fr)
The manuscript entitled «The oncogenic protein kinase MELK is essential for mitotic progression in basal - like breast cancer cells» begins with a functional overexpression screen utilizing a library of open reading frames encoding human kinases. (elifesciences.org)