Therefore, mutation (s) in alternate reading frame protein dysregulate p53 function and play a role in tumor immune evasion. (jbiomed.com)
Upon further investigation, they found that a tumour - suppressor gene called alternative reading frame (ARF), which is normally suppressed in mouse and human iPSCs, remained active in the mole - rat iPSCs. (sciencedaily.com)
Alternate reading frame protein (ARF) complexes with mouse double minute 2 homolog 2 (MDM2), an E3 ubiquitin ligase that regulates the stability of p53 and therefore suppressing tumor growth, it is also involved in the immune response, by modulating the tumor environment [46]. (jbiomed.com)