Sentences with phrase «abnormal blood vessels»

We were very excited to find that our compound, at fairly low doses, could quite significantly block the formation of abnormal blood vessels in this model.

In cats, a condition that results in abnormal blood vessel development to the liver and within the liver can seriously interfere with the organ function.

Currently, wet AMD patients are treated with frequent (as often as once a month) injections into the eye of a drug that blocks one of the major stimulators of abnormal blood vessel growth.

Summary: Use of eye injections of drugs aimed at slowing the growth of abnormal blood vessels in the eye is becoming more common for the treatment of individuals with many eye problems including macular degeneration, diabetic retinopathy and retinal artery or vein blockage.

Retinopathy of prematurity is caused by abnormal blood vessel growth near the retina, the light - sensitive portion in the back of an eye.

However, in 5 % to 25 % of twins with a monochorionic placenta, abnormal blood vessels form inside of the placenta.

The researchers studied data on 497 patients with abnormal blood vessels in the lung, known as pulmonary arteriovenous malformations, who were treated at a specialist HHT clinic at Hammersmith Hospital.

Conversly, the «wet» form of macular degeneration is characterized by the growth of abnormal blood vessels from the choroid underneath the macula which then go on to create «blind spots» in a patient's field of vision.

Since the majority of severe visual loss is caused by abnormal blood vessels growing beneath the retina, a massive effort is underway to identify methods of arresting this process.

Small breed dogs usually have extrahepatic shunts (blood vessels outside of the liver) while larger breeds have intrahepatic shunts (abnormal blood vessels inside the liver).

Earlier research by other scientists has shown that the drug verteporfin, used to treat abnormal blood vessel formation in the eye, acts on the YAP pathway inhibiting the protein's YAP function.

An advanced stage, called proliferative diabetic retinopathy, occurs when abnormal blood vessels grow near the retina, the light - sensitive tissue at the back of the eye.

The device can treat either form of age - related macular degeneration: the dry stage, where the delicate tissues of the macula become thinned and slowly lose function, or the less common wet stage that's caused by the growth of abnormal blood vessels behind the macula.

The same effect was found when the drug was injected into the eyes of mice with abnormal blood vessels like those seen in wet AMD, but, as with the current standard treatment, the drug was only effective for about four weeks since the watery contents inside the eye gradually flushed it out.

Dr. Varma added that the treatments for wet AMD are aimed at blocking the growth of new abnormal blood vessels in the eye and are widely available as opposed to the lack of therapy options for dry AMD, a diagnosis that is typically treated through health lifestyle changes.

Biology may also play a role — for example, a greater propensity towards abnormal blood vessel function during emotional stress, such as exaggerated constriction of coronary or peripheral blood vessels.

A problem in this research arena — called antiangiogenesis — has been finding a compound that is selective, closing off abnormal blood vessels only in the diseased organ while leaving all others intact.

«Finding a way to control angiogenesis not only provides a target for the development of anti-cancer therapies, but may also prove useful in similarly starving abnormal blood vessel growth elsewhere in the body, like in diabetic eye disease.»

In the less common wet AMD, something (scientists aren't sure what) spurs abnormal blood vessel growth, and central vision can be lost in a matter of weeks or days.

For wet AMD, treatments aimed at stopping abnormal blood vessel growth include FDA - approved drugs called Lucentis, Eylea, Macugen and Visudyne used with Photodynamic Therapy or PDT.

Disease - causing angiogenesis is a feature of advanced AMD in which blood vessels in the retina (the structure in the back of the eye that senses and perceives light) begin to grow new, abnormal blood vessels on the surface of the retina.

As the dry form worsens, abnormal blood vessels sometimes grow behind the macula.

But as it progresses, doctors use a procedure known as scatter laser treatment to shrink abnormal blood vessels.

Great for your immune system and liver, reishi mushrooms have been described as having «lifespan - extending properties» because they're helpful in preventing abnormal blood vessels from forming.

Some types of heart disease can be treated with interventional cardiology, which uses special catheters to open blocked valves, measure pressures, or occlude abnormal blood vessels while the patient is under anesthesia.

These are big words for a very small abnormal blood vessel but, in fact, the PDA is the most common congenital heart defect of the dog.

Ultimately, Wars2 provides researchers and pharmaceutical companies a fresh new target for developing treatments for diseases characterized by abnormal blood vessel growth that may be more effective and specific or complementary to what is currently available.

The gene MAP2K1 has previously been linked to some types of cancerous growths as well as to conditions that lead to abnormal blood vessel formation in the head, face or neck.

Pulmonary hypertension develops because of abnormal blood vessels in the lungs, which makes it harder for the heart to push blood through and provide oxygen to the rest of the body.

Roughly 20 percent of patients with age - related macular degeneration suffer from abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped by this new therapy, if it proves to work in clinical trials.

One class of drugs, called vascular endothelial growth factor inhibitors, for example, is designed to thwart the growth of abnormal blood vessels in the eye.

If your baby was born prematurely — especially if he was very premature, had an infection, or needed treatment with oxygen — he's at greater risk for developing certain eye problems, including astigmatism (blurred vision), myopia (nearsightedness), retinopathy of prematurity (abnormal blood vessel growth that can lead to blindness), and strabismus (eye misalignment).

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

However, a recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors.

ROP is a condition that causes abnormal blood vessels to grow in the retina (back of the eye) and can cause retinal detachment, which is a major cause of childhood blindness globally.

In an earlier study, Joslin researchers reported that VEGF, a major growth factor for blood vessels, is elevated in the eye fluids of patients with proliferative diabetic retinopathy and DME, causing leakage and the growth of abnormal blood vessels.

It's thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space.

Working with mice, a multicenter team of researchers has found a new way to reduce the abnormal blood vessel growth and leakage in the eye that accompany some eye diseases.

In the EPR effect, abnormal blood vessels that are «leakier» than normal blood vessels in healthy tissue allow nanoparticles to preferentially concentrate in tumors.

Further research also will help determine which if any of these drugs is safer for glaucoma patients who also have abnormal blood vessel growth.

As a result, the retinal cells degenerate and eventually die, and abnormal blood vessels may grow underneath the retina.

Choroidal neovascularization (CNV), the underlying process causing wet AMD and abnormal blood vessel growth, is the body's misguided way of attempting to create a new network of blood vessels to supply more nutrients and oxygen to the eye's retina.

We know with the wet form that one of the major features is the abnormal blood vessels, and we know that if we stop that we can potentially halt the disease.

When we injected this compound into the eye we saw no signs of toxicity by a number of different measures, and that gave us the confidence to test it in an animal model of choroidal neovascularization (CNV), which is the even more technical term for the angiogenesis, the abnormal blood vessel growth that occurs in wet AMD.

That was the research niche that we set out to explore to see if we could find a new way of targeting the abnormal blood vessel growth that occurs in wet AMD.

«Instead of treating patients after these abnormal blood vessels form in the eye, we may be able to give patients eye drops or systemic medications that prevent their development in the first place.»

Watch a video where AMC's interventional radiology team uses fluoroscopy to close off abnormal blood vessels in the liver.

This is an abnormal blood vessel that allows the blood to bypass the liver, preventing blood to get cleansed by one of the body's filters (the liver).

A special diagnostic procedure allows the surgeon to check the exact location of the abnormal blood vessels prior to surgery.