Sentences with phrase «axon guidance»

Hand R., Polleux F. (2011) Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum.

«A better understanding of the mechanisms involved in axon guidance will offer new possibilities for developing techniques to treat lesions resulting from spinal cord injuries, and possibly even neurodegenerative diseases.»

Several of these are known to be important for neural development in worms — for example, the gene cle - 1 is needed for axon guidance.

Use of pHluorin to assess the dynamics of axon guidance receptors in cell culture and in the chick embryo.

IRCM researchers are studying a process called axon guidance to better understand how axons manage to follow the correct paths.

Misrouting has been attributed to the absence of the directional cues required for normal RGC axon guidance.

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C - terminal fragments.

It's possible, Feigin says, that axon guidance signals — and indeed cell adhesion signals — «are actually being used by tumor cells» to gain advantages over healthy cells.

Many of these long genes encoded proteins involved in neuronal functions, such as axon guidance, calcium signaling, and synapse formation.

«We found that the steepness of the gradient is a critical factor for axon guidance; the steeper the gradient, the better the axons respond to guidance cues,» says Tyler F.W. Sloan, PhD student in Dr. Charron's laboratory and first author of the study.

In the 1990s, scientists found the first of those signaling systems, a family of ephrin proteins that are present in graded fashion in the brain and are involved in axon guidance.

The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

His laboratory implicated endocannabinoids in axon guidance and identified the molecular substrates of Δ9 - tetrahydrocannabinol action in developing neurons.

«This new method provides us with several benefits when compared to previous techniques, and allows us to simulate more realistic conditions encountered in developing embryos, conduct longer - term experiments to observe the entire process of axon guidance, and obtain extremely useful quantitative data,» adds Sloan.

With his vast knowledge, he recommended several topics and I soon became very interested in cell motility and axon guidance.

Our studies reveal previously - unknown roles for glia in pioneer - axon guidance, and suggest conserved principles of brain formation.

The axon guidance pathway associated with promoter mutations is implicated in the involvement of nerve cells in pancreatic cancer.

Prominent among these were promoters affecting pathways that control cell adhesion and axon guidance.

In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to axon guidance.

is needed for axon guidance.