Sentences with phrase «biology approaches»

Our primary research theme is to study scientific questions using integrated systems biology approaches.

The structural information is used for the rational design and development of small molecular inhibitors in combination with chemical biology approaches.

There are also opportunities to explore cancer biology through systems biology approaches.

He continued with a creative molecular biology approach to neuroscience with faculty positions at Stanford University from 1982 onward in the Departments of Biological Sciences and Molecular and Cellular Physiology, and at the Howard Hughes Medical Institute, Stanford University Medical Center.

Using synthetic biology approaches, I am engineering fluorescent organisms to monitor mechanical sensing systems in response to pressure.

We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.

Our proof of concept study suggests this network biology approach could help us identify new medications for epilepsy, and the methods can also be applied to other diseases.»

Along with colleagues, he founded Ontogeny Inc., a biotechnology company based in Cambridge, Massachusetts that aims to use developmental biology approaches to create new treatments for diseases such as diabetes and Parkinson's.

The introduction of increasingly powerful structural biology approaches has allowed researchers to characterize the structures of mutant proteins involved in cancer, such as RAS, and other molecules in greater detail than had been possible previously.

«A synthetic biology approach for a new antidote to coral snake venom.»

His group is now blending large - scale systems biology approaches with mechanistic and structural biochemistry to systematically annotate the functions of these mitochondrial proteins, including many that harbor causative mutations in human disease.

But he's less optimistic than Altman about big pharma committing to a computational biology approach anytime soon.

Classic cell biology approaches study averaged results collected from many cells meaning that key cell - to - cell differences are lost.

The INMG intends to develop cutting - edge basic and applied research on the nervous and muscular systems focused on integrative molecular and cellular biology approaches.

Kilian's main research interests comprise the functional exploration of cellular signaling networks by the development of specific chemical probes and chemical biology approaches apt to identify new therapeutic targets relevant for the treatment of human disease.

The systems biology approach often involves the development of mechanistic models, such as the reconstruction of dynamic systems from the quantitative properties of their elementary building blocks.

A sys tems biology approach to molecular studies of the brain is needed that is compatible with this extreme pleiotropy and polygenicity.

Her ongoing clinical training through the Institute for Functional Medicine uses a systems biology approach when working with those who suffer from chronic and acute conditions to help them find their path to healing.

Students receive training with a «systems» biology approach through courses, bench work, lab discussions and publications spanning a broad range of muscle - biology questions using studies at the level of single cells, tissues, animals and humans.

They used sophisticated molecular biology approaches, together with experiments that deleted specific genes from the animal models, to fill in the steps that led from Vegf signaling to Dll4 activation.

There was keen interest in both using synthetic biology approaches to confront invasive specie, and the role Mauritius could play in innovating strategies.

Validation of N - myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Her laboratory has successfully combined electrophysiological expertise with molecular and cell biology approaches to better understand complex mechanisms underlying the memory process in mouse models of AD.

Along with colleagues he founded Ontogeny Inc., a biotechnology company based in Cambridge, Massachusetts, that aims to use developmental biology approaches to create new treatments for diseases such as diabetes to Parkinson's.

In addition, application of his personalized structural biology approach has revealed insights into how EGFR mutations influence cancer progression, recurrence and drug resistance.

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

A systems biology approach integrating genome ‐ wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control.

His group employs both the bottom - up, molecular biology approach and the top - down, organism approach, hoping that by «having two ways of thinking in the lab and allowing people to share thoughts and projects,... we could probably be an excellent lab and try to integrate the whole spectrum,» he says.

The systems biology approach, where cross-disciplinary scientists work together as a team, can potentially make important contributions to research.

To make their discovery, Rust and his colleagues had to separate metabolism from light exposure, and they did this by using a synthetic biology approach to make photosynthetic bacteria capable of living on sugar rather than sunlight.

Michael Katze, University of Washington microbiology professor and lead investigator for collaborative NIH programs that use systems biology approaches to investigate viral - host interactions, puts it bluntly: «The NIH is impatient with basic science,» he says.

BioSim is an E.U. - funded network of researchers investigating biomedical questions — particularly pharmacological ones — using a systems - biology approach.

New institutions around the world are gathering interdisciplinary teams of biologists, mathematicians, and computer specialists to help promote systems biology approaches.

Borenstein and his team use a systems biology approach and apply sophisticated computer modeling to understand the structure, function, and dynamics of the microbiome.

But the changing world of drug safety also requires that scientists adopt a systems biology approach.

«We should use a systems biology approach to look at entire pathwaywide or organismwide analysis at a systems level, to understand how individual genes, proteins and other components work together to regulate a property or a behavior.»

In the research community, we've got to develop systems biology approaches, such as this one, that take a more sophisticated approach to get us where we need to be.»

The Center has pioneered the systems biology approach to research, which utilizes state - of - the - art technology, fosters collaboration between scientists, and allows for a comprehensive understanding of the interactions between pathogens and their hosts.

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

By using a systems biology approach, researchers deliberately move away from the classic reductionist manner of looking at molecules in isolation to study biological systems in their entirety.

As analytical devices continue to improve and bioinformatics systems get more powerful, yet easier to use, systems biology approaches will stretch across more areas.

The scientists used a comprehensive systems biology approach to explore the relationship between genes, low - dose radiation, and cancer.

Metabolic phenotyping and systems biology approaches to understand neurological disorders

From correlation to causation: analysis of metabolomics data using systems biology approaches — Antonio Rosato, Metabolomics