Sentences with phrase «cardiac tissue»
Cardiac tissue refers to the specialized type of tissue that makes up the heart. This tissue helps the heart contract and pump blood throughout the body, allowing it to function properly. Full definition
It's so unusual in the heart that doctors often write up their findings for medical journals when the tumors are found in cardiac tissue.
fortune.com
The researchers believe this is the first 3D in vitro cardiac tissue with three cell types that can beat together as one entity rather than at different intervals.
This is due to the progressive loss of cardiac strength and irreversible degeneration and remodeling that occurs in cardiac tissues.
Researchers at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) and their colleagues at the University of Bayreuth investigated whether an artificial silk protein developed in the laboratory could be suitable for engineering cardiac tissue.
«Growing beating cardiac tissue from stem cells: New model for early heart development.»
The creation of cardiac tissue - like constructs could offer an effective and convenient «woundplast» for repairing myocardial infarction.
Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.
«Making in vitro 3D cardiac tissue has long presented a challenge to scientists because of the high density of cells and muscularity of the heart,» said Dmitry Rogozhnikov, a chemistry PhD student at York.
«Spider silk protein may be useful for engineering artificial cardiac tissue.»
In experiments to be published Tuesday, July 14, in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchambers.
A previous study from the MGH team found that injecting B cells into cardiac tissue damaged by a heart attack improved structural and functional recovery in an animal model.
Finally, the authors also discovered similar elevated cardiac repair following the transient overexpression of CAMKK1 in infarcted cardiac tissue via the injection of a CAMKK1 expression plasmid.
The particles delivered fragile but potent RNA molecules into macrophages, inflammatory cells that swarm into cardiac tissue after a heart attack.
We obtained high - quality cardiac tissue - like constructs (CTLCs) by cultivating hiPSC - CMs on aligned nanofibers made of biodegradable polymer.
Researchers from the Institute for Integrated Cell - Material Sciences (iCeMS) of Kyoto University and the Department of Cardiovascular Surgery of Osaka University have developed effective and convenient Cardiac Tissue - Like Constructs (CTLCs) for repairing myocardial infarctions.
These CMs form myofibril - aligned, multi-layered and 3D - organized Cardiac Tissue - Like Constructs (CTLCs), which show robust drug response and may be readily used for repair of injured rat hearts with myocardial infarctions.
The work conducted by the researchers from Erlangen and Bayreuth and the possibilities of printing artificial silk proteins using 3D printing technology therefore represent the first steps towards future methods for engineering functional cardiac tissue.
Because they are interested in human heart failure, Lavine and his colleagues developed a method to progressively damage mouse cardiac tissue in a way that mimicked heart failure.
«Engineered cardiac tissue model developed to study human heart.»
«This project utilizes innovative technology and applies it to a critical health issue, minimizing cardiac tissue loss from a heart attack» explains Steven Krosnick, M.D., Director of the NIBIB Program for Image - Guided Interventions.
They did this by freezing the zebrafish cardiac tissue, causing the cell membranes to burst and allowing the researchers to retrieve the ECM, a process called decellularization.
Then there are stem cells, which tantalize with their myriad possibilities: allowing diabetics to throw away their insulin, growing healthy cardiac tissue after a heart attack, restoring function to people with spinal cord injury (for which the Food and Drug Administration just approved the first embryonic stem cell trial).
GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].
In addition to growing new skin for burn victims, cells from hair follicles could potentially be used to engineer vascular grafts and possibly regenerate cardiac tissues for patients with heart problems.
The zebrafish heart robustly regenerates missing or damaged cardiac tissue following a partial ventricular resection procedure in as little as 30 - 60 days.
Specifically, application of a prefabricated cardiac tissue patch to prevent dilation and to improve pumping efficiency of the infarcted heart offers a promising strategy for making stem cell therapy a clinical reality.
Together with the van Oudenaarden lab we have performed tomo - seq on zebrafish embryos at various stages and isolated cardiac tissues.
Davis» lab studied cardiac tissue derived from children of different ages undergoing surgery for congenital heart defects.
In advanced cases, the degenerated cardiac tissues are replaced with connective tissues (remodeling) and which causes stiffness in the tissues.
Scientists in Korea have designed a crablike robot that is smaller than the thickness of a fingernail and powered by contractions of cardiac tissue.
Although the 3D cardiac tissue was created at a millimeter scale, larger versions could be made, said Yousaf, who has created a start - up company OrganoLinX to commercialize the ViaGlue reagent and to provide custom 3D tissues on demand.
To address this challenge and engineer complex 3 - D tissues, researchers at the Brigham and Women's Hospital and Harvard Medical School in Boston and the University of Sydney in Australia were able to combine a novel elastic hydrogel with microscale technologies to create an artificial cardiac tissue that mimics the mechanical and biological properties of the native heart.
In experiments published in the journal Nature Communications, the researchers used biochemical and biophysical cues to prompt stem cells to differentiate and self - organize into micron - scale cardiac tissue, including microchambers.
Researchers from the Gladstone Institutes, in collaboration with scientists at UC Berkeley, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.
In addition, the substance used to stick cells together (ViaGlue), will provide researchers with tools to create and test 3D in vitro cardiac tissue in their own labs to study heart disease and issues with transplantation.
To make this advance, Costa and colleagues cultured human engineered cardiac tissue, or hECTs, for 7 - 10 days and they self - assembled into a long thin heart muscle strip that pulled on the end - posts and caused them to bend with each heart beat, effectively exercising the tissue throughout the culture process.
SAN FRANCISCO, CA — Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.
Olive consumption is followed with the release of glutathione in cardiac tissue and the downregulation of carcinogenic activity throughout the body.
«For 2D or 3D cardiac tissue to be functional it needs the same high cellular density and the cells must be in contact to facilitate synchronized beating.»
The 3 - D mapping technology allows Perin to determine in real time the viability of cardiac tissue and decide which areas are hospitable to stem cells.
Jana Petzold of the Erlangen team headed by Prof. Engel and Tamara Aigner from Prof. Scheibel's Bayreuth working group collaborated in investigating the suitability of the silk protein eADF4 (κ16) produced in the laboratory for the production of cardiac tissue.
Silk could be the key to artificial cardiac tissue.
Prof. Dr. Felix Engel of the Department of Nephropathology at Universitätsklinikum Erlangen had examined the properties of silk from the Indian silkworm and demonstrated its particular suitability as scaffolding material for engineering cardiac tissue.
«We hope that our human engineered cardiac tissues will serve as a platform for developing reliable models of the human heart for routine laboratory use,» said Kevin D. Costa, Ph.D., a researcher involved in the work from the Cardiovascular Cell and Tissue Engineering Laboratory, Cardiovascular Research Center, Icahn School of Medicine at Mt. Sinai, in New York, NY.
In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 %.
To assess whether CAMKK1 can improve cardiac tissue repair, the group overexpressed CAMKK1 in MSCs and injected the modified MSCs or their conditioned medium (CM) into infarcted cardiac tissue at the time of AMI.
Recent Scientific projects as principal investigator: • 2003/2005 (EU V Frame Program): «International Bank of DNA, cell lines and nerve - muscle - cardiac tissues» - «European Network of Human Biological Material for Rare Diseases - Eurobiobank».
In summary, a number of promising stem cell products are currently tested in clinics in attempt to repopulate the infarcted myocardium and bring a solution to the patients suffering from the damage to the cardiac tissue.