Sentences with phrase «cellular targets»

In addition, there were no signs that the engineered T cells caused side effects by hitting the wrong cellular targets in the mice.

Once inside, they can disrupt several cellular targets, including DNA, RNA, and proteins.

This demonstrates the numerous opportunities for data mining, designing drug candidates, developing models to predict biological activity, and studying interactions between cellular targets and synthetic molecules.

DNA sequences designed to either stimulate a specific immune response or to down - regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

Identification of cellular targets of microRNA - 181a in HepG2 cells: a new approach for functional analysis of microRNAs

Our results identify cellular targets for future functional investigations, and demonstrate that connectomes can provide key insights into neuronal computations.

Future work will focus on identifying cellular targets of ampulexins, and potentially generating a useful animal model for the study of Parkinson's disease treatments.

Lung cancer causes the most cancer - related deaths in the United States, and researchers are searching for new cellular targets to increase survival rates.

Allison spent the next couple of years pitching his work to biotechs and big pharmaceutical companies, hoping to find one that would develop an antibody that could block the same cellular target in people.

The Company's T2 Magnetic Resonance platform (T2MR) enables detection of pathogens, biomarkers and other abnormalities in a range of unpurified patient sample types, including whole blood, plasma, serum, saliva, sputum and urine, and can detect cellular targets at limits of detection as one colony forming unit per milliliter (CFU / mL).

Single - cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs» main cellular target in bacteria evolves to become...

The significance of these studies will lead to a better understanding of cellular targets by DENV, which can identify new potential therapeutics to reduce viral levels during infection and lessen the severity of disease.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

As they die, these cells release proteins, called cytokines, that cause inflammation and that attract healthy cellular targets promoting repeated rounds of infection and cell death.

Patterson, K. I., Brummer, T., O'Brien, P. M. & Daly, R. J. Dual - specificity phosphatases: critical regulators with diverse cellular targets.

Wahl was on the tenure track in 2002 as a pathology researcher at Duke University, identifying cellular targets for cancer therapies, when funding dried up for her research and she consequently failed to get tenure.

Taken together with the fact that several cellular target are addressed, this could provide a novel approach for tuberculosis treatment.

Therefore, the identification of cellular and molecular mechanisms underlying neuron - astrocyte communication will help to a better understanding of the mechanisms of brain phsyiology as well as to appropriately identify cellular targets to direct therapeutic approaches for the future treatment of several brain diseases.

But its cellular targets have remained unknown.

Another Bristol - Myers Squibb experimental compound can be taken orally but isn't very selective in terms of its cellular targets in the body.

In fact, research indicates that the pain of hyperalgesia occurs because the morphine latches on not only to cellular targets that reduce pain sensation but to other «non-opioid» targets that result in activation of pain - sensing neurons.

Barnes also plans to uncover how the virus gains illicit entry into cells by examining the structural changes that help the virus lock into a cellular target.

OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF - alpha functions, thereby affecting cell death.

Dr. Gudkov continued, «Recognizing SAMs as a cellular target of aging allowed us to timely redirect our effort from senolytic to «SAMolytic» drugs and to accelerate the development of novel anti-aging therapeutics.»

A major lab project involves the study of prohormone convertase enzymology and potential dominant negative effects (effects of oligomerization, the role of the inhibitory tail domain, and cellular targeting).

His lab is currently investigating the organization and function of a vastly underexplored but potentially highly important neural pathway from the cholinergic MT to DA neurons, and seeking potential causes, as well as molecular and cellular targets for treating schizophrenia.