Sentences with word «connexin»

hGDAsBMP also expressed connexin 43 (CX43), glutamate transporter 1 (GLT - 1), AKAP12 and glia - derived neurotrophic factor (GDNF), all of which are expressed in the astroglial lineage [23]--[25].

The marked similarity between the voltage gating behavior of UNC - 7S and L could indicate that the amino terminus has little effect on voltage gating of these channels, in stark contrast to what has been found for connexins (summarized in [35]-RRB-; alternatively, it is possible that both unc - 7 expression constructs might utilize the internal start site (M121) and similarly produce UNC - 7SR.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

Here we used this approach to show that newly synthesized connexin43 was transported predominantly in 100 - to 150 - nanometer vesicles to the plasma membrane and incorporated at the periphery of existing gap junctions, whereas older connexins were removed from the center of the plaques into pleiomorphic vesicles of widely varying sizes.

In previous work, Dr. Ryosei Minoda, head of the Department of Otolaryngology at Kumamoto General Hospital, reported that hearing loss was restored by gene therapy to the inner ear of Connexin 30 deficient fetal mice.

Association between connexin 40 and potassium voltage-gated channel subfamily A member 5 expression in the atrial myocytes of patients with atrial fibrillation.

In 1997, he contributed to the development and validation of the OLA - PCR cystic fibrosis diagnostic panel commercialized by Applied Biosystems, and to the identification of the autosomal recessive neurosensory deafness connexin 26 gene.

From numerous studies in the Xenopus paired oocyte system and various cell culture systems, a reasonable assumption might be that if two cells express the same connexin or innexin and lie in close membrane apposition, gap junctions will probably be established between them; this assumption has not been investigated rigorously in vivo.

Given that the gating profile when the UNC - 7S or L side is relatively negative (UNC - 9 positive) is similar to that of homotypic UNC - 7, and when UNC - 9 is relatively negative the limited gating response resembles UNC - 9 homotypic, we conclude that these members of the innexin family close the series gate on the negative side (this is the reverse of most, but not all, connexins [7]-RRB-.

Individual connexin, innexin and pannexin proteins have all been shown to form gap junction channels with similar properties as assayed in paired Xenopus oocytes (for example, [4, 7, 8]-RRB-.

Meanwhile, on Tuesday the British telecommunications regulator, Ofcom, announced the names of the carriers that have qualified to take part in upcoming frequency auctions in that country: EE, Hutchison 3G UK (which trades as the Three network), Vodafone, Telefonica, Airspace and Connexin.

The GJB6 gene encodes the CONNEXIN 30 protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.

Cell transplantation can compensate for missing CONNEXIN and may improve hearing loss by adding properly functioning CONNEXIN proteins.

By efficiently differentiating inner ear cells from human iPS cells, it was possible to produce a large number of target cells and a large number of protein expressions unique to inner ear cells other than CONNEXIN.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

They then transplanted progenitors of the inner ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes.

First, the research team succeeded in efficiently inducing inner ear cells expressing inner ear specific proteins, such as CONNEXIN 26, CONNEXIN 30, and PENDRIN, from human iPS cells.

However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

Connexin - 45 plays a critical role in the conduction and coordination of spontaneous contractions in collecting lymphatic vessels Jorge Castorena - Gonzalez, University of Missouri

For example, hGDAsBMP express higher levels of such astrocyte - related genes as glutamate transporter 1, connexin 43, and AKAP12, which are relevant to maintaining tissue homeostasis in the CNS as well as reducing astrogliosis and neuronal death after injury, mediating glutamate uptake and promoting blood - brain barrier formation [23], [24], [58]--[61].

In contrast, CNTF treatment did not induce expression of GLT - 1, connexin 43, AKAP12, or GDNF.

Such rectifying behavior has been reported for some connexins, and has been shown to arise from the pairing of two hemichannels with different ion selectivities [34].

Other factors include proteins like E-cadherin, connexins and paxillin.