Sentences with phrase «effect on the disease»

The associated alleles were common in the studied populations and all had only small effects on disease risk [123].

Professor Clive Holmes, senior author from the University of Southampton, says: «These are very interesting results which build on previous work we have done that shows that chronic inflammatory conditions have a detrimental effect on disease progression in people with Alzheimer's disease.

Dietary interventions must be implemented to promote sustained beneficial effects on disease markers and long - term adherence.

«If you find the right peptide, you can really influence a large repertoire of B and T cells and have a profound effect on the disease,» at least in mice, says immunologist Bevra Hahn of the University of California.

So far, GWAS efforts have reported 80 robust associations, largely involving common (MAF > 5 %) variants that have very small effects on disease risk.

Whilst established to examine possible safety issues with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior clinical lecturer and honorary consultant rheumatologist; Arthritis Research UK Epidemiology Unit, The University of Manchester; and an investigator in the study.

This coupling, termed O - GlcNAcylation, has favorable effects on disease - injured cells, including myocytes.

«But it's remarkable that lowering levels of a single gene could have such a strong effect on the disease.

«A simple additive, which is completely nontoxic, could have a positive effect on disease, even rescuing regorafenib and similar therapies from resistance.»

Currently available treatments have only modest effects on the disease and its symptoms, which underlines the importance of identifying preventive measures.

«Induced pluripotent stem cells used to show statin effects on diseased bone.»

«Our hypothesis was, if a disease is characterized by certain changes in gene expression and if a drug causes the reverse changes, then that drug could have a therapeutic effect on the disease,» he says.

It might be possible that nearby rare causal variants were in LD with the tag SNP, and these (not the tag SNP) exerted the causal effect on disease risk.

Unpublished work also shows cranberry juice has potent effects on disease - causing bacteria, but that the effect is temporary.

«We focused on children because early exposure can have long - term effects on disease outcomes,» says Rainbow Vogt, lead author of the study.

Raw milk is full of fat and water - soluble vitamins, numerous minerals, trace elements, all eight essential amino acids, more than 60 enzymes and the omega - 6 fatty acid — CLA — that has an amazing effect on diseases such as insulin resistance, cancer, and cardiovascular disease.

And new research from The Rockefeller University and the Icahn School of Medicine at Mt. Sinai suggests these newly discovered commonalities may open the door to «engineered» gut flora who can have therapeutically beneficial effects on disease.

Their findings — that nanotubes and vesicles are an important part of the communications process — show that the extracellular vesicles contribute to the complexity of African trypanosomiasis through the transfer of virulence factors between parasites and inadvertent interaction with host cells, which has a profound effect on disease, the study notes.

For the Parkinson's program, for example, BlueRock will have to determine whether introducing the neurons has an effect on the disease and possibly reverse its effects.

Liepa, an expert on diet's effect on disease and immune function, says in the summer issue of Eating Well magazine that certain foods can lower inflammation as indicated by the level of creactive protein, or CRP, in the blood.

The trial was designed to assess the safety of MSCs rather than the effect on disease.

Individuals with abnormalities on their MRI scans at the first appointment were compared to those without to examine the effect on disease progression.

These bacteria may just be at too low a level to have an effect on the disease, but augmenting them to higher abundances may provide a beneficial effect,» Hoyt said.

«This is a promising new approach to lowering tau, but we have to test whether it is safe in people, and whether it actually lowers tau, as it is designed to do, before we get to the question of whether it has any effect on the disease.

In a study led by the University of Oklahoma with ORNL, the University of Tennessee and Saint Louis University, lab experiments were combined with supercomputer modeling to identify molecules that boost antibiotics» effect on disease - causing bacteria.

Says Herbert, «We discussed the enormous number of chemicals in our environment and how little we know about chronic, low - dose, multiple exposures and their effect on diseases like autism.

We found no coding mutations that followed the risk or non-risk haplotypes suggesting that regulatory mutations exert the effect on disease.

And finally they can provide an alternative to steroid treatment for patients who either can't take steroids or find that steroids have no effect on their disease.»

When mutant genes in only the microglia were silenced, the scientists found almost no effect on disease onset, however the disease progression was significantly slowed.

To test this effect on disease, the researchers used a mouse model of MS and treated the animals with a drug that inhibits SIRT1.

Identifying these, and quantifying their effects on disease risk, should lead to diagnostic and therapeutic approaches for improving human health.

Fennel appears to increase the efficacy of the antibiotic, streptomycin when used against tuberculosis, although it shows no effect on the disease - causing bacteria themselves.

You have to factor in long - term sustainability, requirements to manufacture it on the large scale, the effects on disease spread, whether or not it's even reasonably possible with how things are at current, and even such lovely things as Hurricane Dolly.