Sentences with phrase «epithelial barrier»
The phrase "epithelial barrier" refers to a protective layer of cells called epithelial cells that act as a barrier, separating and protecting different parts of the body. This barrier helps to prevent harmful substances, pathogens, and toxins from entering certain areas of the body, while allowing essential nutrients and molecules to pass through. Full definition
«However, prolonged exposure [to Alternaria] leads to disruption of epithelial barrier function that would ultimately reduce mucociliary clearance,» the researchers wrote.
sciencedaily.com
Efficient wound healing is required to maintain the integrity of the intestinal epithelial barrier because of its constant exposure to a large variety of environmental stresses.
Schmitz, H., Barmeyer, C., Fromm, M., Runkel, N., Foss, H.D., Bentzel, C.J.,... Schulzke, J.D. (1999) Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.
Active eosinophilic esophagitis is characterized by epithelial barrier defects and eosinophil extracellular trap formation Simon D et al..
The research team, led by Georgia State University and the University of Michigan, wanted to understand how a wound heals in the intestine because in IBD, which includes Crohn's disease and ulcerative colitis, damage to the intestinal epithelial barrier allows bacteria in the intestine to go across the barrier and stimulate the body's immune system.
These flaws, called epithelial barrier defects, feature in human disorders, including in the skin, gut, and lung.
In addition, the combination of defective epithelial barrier and abnormal epithelial cell extrusion observed in this mouse model may be further exploited to study the role of Alix in cancer.
Loss of Alix (right) also results in defective orientation of motile cilia in the ependyma — the protective epithelial barrier between brain and cerebrospinal fluid.
Probiotics strengthen the intestinal epithelial barrier so that the damaging contents of the gut remain out of our bodies.
According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight junction proteins, which regulate transport into and between cells.
But in an interesting twist, a beneficial bacterium, Lactobacillus plantarum, helps mitigate the virus - induced inflammatory response and protects gut epithelial barrier.
Efficient repair of the epithelial barrier is critical for suppressing inflammation and reestablishing intestinal homeostasis.
The researchers thus suspect that they play a major role in ensuring the integrity of the epithelial barrier function.
Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.
Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the epithelial barrier.
The epithelial barrier in the choroid plexus of the brain is the blood - cerebrospinal fluid interface.
«Our study unravels the central role that Alix plays not only in preserving the general architecture of the epithelium and the epithelial barrier but also how this protein contributes to the maintenance of brain homeostasis.»
«This detection activates cell - signaling pathways that produce antimicrobial peptides, suppress the growth of harmful bacteria, and maintain the integrity of the intestine's epithelial barrier.
These changes are so fundamental that they lead to prominent alterations in cell shape and loss of cell polarity, alterations that ultimately affect the epithelial barrier,» explained d'Azzo.
In each route of infection, spores or vegetative bacteria must translocate through an epithelial barrier in order to disseminate and cause disease.
Together with the gut - associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens.
Both trifluridine and idoxuridine have low solubility, and as such, their intraocular penetration is low unless the epithelial barrier is altered.