Sentences with word «filovirus»

«The work on antibodies isolated from survivors of filovirus infections, including Marburg and Ebola, was started by James Crowe's laboratory at Vanderbilt University together with our laboratory about 3 years ago,» said virologist Alex Bukreyev, professor at UTMB and co-corresponding author.

Feldmann and his colleagues are reporting their results at the 7th International Symposium of Filoviruses in Washington, D.C., this week.

Had the then -67-year-old Hoffman — who brought mainstream culture face to face with autism in Rain Man and went mano a mano with an Ebola - like filovirus in Outbreak — never quite broken character from his 1982 film Tootsie?

The team is also working on prevention of related Ebolavirus members Sudan virus (SUDV) and Bundibugyo virus (BDBV), and the related filovirus Marburg virus.

One of these chemical structures, benzoquinoline, showed antiviral activity against Ebola virus and was also active against another deadly filovirus, Marburg virus.

The SUNY team suggests that the NIRVs in mammals may help clarify perplexing riddles about filoviruses.

Fedson says that many scientists who study filoviruses like Ebola have yet to catch on to the idea of treating the immune response.

Although outbreaks are rare, Ebola virus, Marburg virus, and other so - called filoviruses periodically cause massive hemorrhaging in humans, chimpanzees, gorillas, and other primates.

Taylor and his colleagues have now found fossil filovirus genes buried within the genomes of a dozen species, but none in any primates.

«The Ugandan scientific community and general population were very interested in participating in vaccine research relevant to Ugandan public health, including filovirus vaccine research,» said Hannah Kibuuka, M.D., the principal investigator of the RV 247 Ebola study in Uganda.

Developed and optimized protocols for detection of hemorrhagic fever viruses including Filoviruses, Arenaviruses and Bunyaviruses (Ebola, Marburg, Lassa, Machupo, CCHF, Rift Valley Fever and others).

Her work included the genome sequencing of the Ebola and Marburg filoviruses and Lassa Fever, as well as joint work to develop possible therapies.

The study, published by EcoHealth Alliance's Dr. Kevin Olival and Dr. David Hayman from Massey University, reviewed all of the current literature on filoviruses — the class of viruses that include both Ebola and Marburg virus — and took a critical look at the ecological and virological methods needed to understand these viruses to protect human health.

The culprit should also have chronic infection with filovirus — the family to which Ebola belongs — but not show symptoms.

The WHO filovirus clinical working group, convened in response to the current outbreak, discussed the evidence on convalescents» serum at a meeting in Geneva, Switzerland, at the end of July, says Bausch, who is part of the group.

There are no approved drugs to treat Ebola virus or other filovirus infections, so there is a critical need for new therapeutic approaches.

Diagnostic reverse - transcription polymerase chain reaction kit for filoviruses based on the strain collections of all European biosafety level 4 laboratories

«The increasingly frequent outbreaks of filoviral HF in Africa evidenced by the current rapidly spreading outbreak in Guinea, Liberia and Sierra Leone illustrate the clear and present danger filoviruses represent to human health,» stated UTMB's Thomas Geisbert, professor of microbiology and immunology.

Although several mouse antibody - based treatments have provided protection against Ebola Zaire in animal models, there are no available therapeutics based on antibodies from human survivors and no universal treatments against multiple filoviruses, including Ebola Sudan and Ebola Bundibugyo.

Taylor suggests that finding NIRVs in New World marsupials indicates that there may be unknown filoviruses in South America, where people sometimes die of unexplained hemorrhagic fevers.

They arrived at that estimate by showing that the Norway rat and the house mouse, which diverged from each other somewhere between 12 million and 24 million years ago, have the same filovirus gene pieces integrated at the same places on the same chromosomes.

Presentation: «Nucleotide Prodrug GS - 5734 Is a Broad - Spectrum Filovirus Inhibitor that Provides Complete Therapeutic Protection Against Ebola Virus Disease in Infected Non-human Primates.»

Finding comparable safety and immunogenicity in U.S. and Ugandan populations provided proof of principle that a protective, multivalent filovirus vaccine is attainable.

Salvador B, Sexton NR, Carrion R, Nunneley J, Patterson JL, Steffen I, Lu K, Muench MO, Lembo D, Simmons G. Filoviruses utilize glycosaminoglycans for their attachment to target cells.

However, in the 40 years since the first Ebola outbreak, fruit bats have been found to be probable reservoirs for filoviruses — the type that causes Ebola — and the Ebola genome and antibodies have been found in bat and rodent species in East and West Africa.

«Our results provide a roadmap to developing a single antibody - based treatment effective against not only infections caused by Ebola Zaire virus, but also caused by related filoviruses.»

Comprehensive panel of real - time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses

Because three kinds of bats from the region are believed to harbor the deadly filovirus.

«These data provide the basis for understanding the immune response to filovirus infections in humans,» said Bukreyev.

The largest outbreak on record for the filovirus family was caused by Ebola virus in West Africa between 2013 and 2016, resulting in more than 28,000 infections and more than 11,000 deaths.

Ebola virus, a member of the filovirus family, is an enveloped, single - stranded RNA virus that causes severe disease in humans.

«A nice thing about the filovirus field is that it was populated by very straightforward, salt - of - the - earth people,» she says.

The viruses in question belong to two families: Filoviruses, which include Ebola and Marburg, and Bornaviruses, which causes neurological diseases in certain animals, such as horses.

That said, it's still too early to know whether Bornaviruses and Filoviruses are really overrepresented, says Derek Taylor, an evolutionary biologist at the University at Buffalo in New York.

But equally intriguing was how few different families of RNA viruses turned up: just Bornaviruses and Filoviruses.

Of these, only half have ever been tested for filovirus, says Peterson.

The researchers engineered a DNAzyme with two loops: one to detect to detect the Marburg sequence, and another to detect a sequence common to all filoviruses, which includes Marburg and all strains of Ebola.

Her team designed logic gates to respond to 15 - nucleotide segments of DNA from the genomes of two filoviruses, Ebola and Marburg.

This gate is activated only when the filovirus sequence is present, but the Marburg sequence is not; activation cleaves a substrate strand labelled with a pink fluorescent dye.

Adding the filovirus sequence without the Marburg sequence would generate a pink «E» in the wells.

The question is, can these antibodies protect against a future infection with the virus and related filoviruses?

For instance, under the new rules, Marburg disease (named after a city in Germany) might have been called filovirus - associated haemorrhagic fever 1, while Ebola (named after a river) might have been filovirus - associated haemorrhagic fever 2.

Under new WHO guidance, it would now get a name like «filovirus - associated haemorrhagic fever 2.»

In a study reported online this week in BMC Evolutionary Biology, the researchers conclude that filoviruses have existed for tens of millions of years.

Filoviruses are RNA viruses that don't carry the gene for reverse transcriptase, yet that hasn't stopped them from somehow leaving their mark.

Indeed, bats have long been a prime suspect for a filovirus reservoir.

Some reports based on the estimated mutation rate of this virus family have suggested that filoviruses are a mere 10,000 years old, but Derek Taylor, an evolutionary biologist at the State University of New York (SUNY), Buffalo, has found a new way to gauge their age.

For the published broad agency announcement, see the April 29, 2016 solicitation, Advanced Development of Multivalent Vaccine Candidates for Filovirus and Lassa Fever.

Outbreaks of Ebola and Marburg virus, both filoviruses, have occurred sporadically since their discovery in 1976 and 1967, respectively.