Sentences with phrase «human kidney»

There are other compounds under study for a particular form of human kidney disease.

The technique also helps scientists examine the effects of drugs on human kidney cells.

In addition, the findings may help guide emerging stem cell - directed technologies to generate normal kidney structures for studying and treating human kidney disease.

Three new research articles compare human kidney development with a well - studied mouse model of kidney development to identify shared and novel features.

For these patients, even a temporarily functional pig kidney might be valuable as they wait for an available human kidney.

There are almost one million of these structures in a single human kidney.

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

Immunohistochemistry of paraffin - embedded human kidney tissue slide using 60008 -1-Ig (beta Actin antibody) at dilution of 1:500 (under 10x lens) heat mediated antigen retrieved with Tris - EDTA buffer (pH9).

Immunohistochemical staining of paraffin - embedded human kidney using Stanniocalcin 2 antibody (10314 -1-AP) at a dilution of 1:50 (10x objective).

Immunohistochemical of paraffin - embedded human kidney using 60004 -1-Ig (GAPDH antibody) at dilution of 1:50 (under 10x lens)

Now, with the team's newly engineered human kidney glomerulus - on - a-chip, researchers also can get in vitro access to the kidney's core filtration mechanisms that are critical for drug clearance and pharmacokinetics, in addition to studying human podocytes at work.

While past studies have analyzed kidney tubular cells cultured under flow conditions in vitro, this is the first report of a toxicity study using primary human kidney proximal tubular epithelial cells in a microfluidic «organ - on - a-chip» microdevice.

So the scientists inserted the taste genes into human kidney cells that were growing in dishes.

«We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into kidney structures that resemble those found in a normal human kidney.

(ref) Phosphate binders are standard treatment in late - stage human kidney failure as well.

Zombie fans and anatomists alike will appreciate this handmade Human Kidney Lollipop Chocolate Candy Mold by Concepts in Candy.

Indeed, the team was able to culture nanobacteria from all 30 human kidney stones they examined.

Human kidneys filter atrazine, and humans don't spend a lot of time swimming in pesticide - laced water, the way frogs do.

«Device emulates human kidney function: Model kidney could replace animal, human testing.»

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

«First, by genetically modifying the iPS cells, we created human kidney tissue in vitro with green fluorescence.

«We analyzed human kidney development, identifying features that distinguish our kidney from its well - studied mouse counterpart.

Salk Institute scientists have discovered the holy grail of endless youthfulness — at least when it comes to one type of human kidney precursor cell.

To upgrade their DNA «switches,» Wong and his colleagues steered clear of transcription factors and instead switched human kidney cell genes on and off using scissorlike enzymes that selectively cut out snippets of DNA.

The test drug slowed the growth of kidney cysts in two mouse models and in cell cultures of human kidney cysts, the study showed.

Singh cautions that gallium can harm human kidneys when taken intravenously, so it's too early to peg a safe dose in humans.

Researchers from Australia generated primitive human kidney tissues from adult stem cells, a recent study says.

Immunohistochemistry - Paraffin: Emx1 Antibody - Staining of human kidney shows moderate nuclear positivity in cells in a subset of renal tubules.

«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.

However, the next step in this line of research will be to study the effects of Tuba depletion in the kidneys of mice, since murine kidneys are more like human kidneys than those of zebrafish.

Human kidneys genetic material was analysed in the study in a search for genes that could be causes of high blood pressure.

It had been used in human medicine since 1972 when it was discovered that it helped in preventing rejection of transplanted human kidneys.

As a result of these findings, the team were able to conclude that the Drosophila model was an effective and accurate model of human kidney disease.

«Mouse and human kidney development compared: Findings may lead to advances in the study and treatment of kidney disease.»

The researchers inserted the genes for the 25 subtypes into human kidney cells (an easier feat than working with real taste cells).

«This new finding could hasten progress to model human disease, find new therapeutic agents, identify patient - specific susceptibility to toxicity of drugs and may one day result in replacement of human kidney tissue in patients with kidney disease from cells derived from that same patient,» said author Joseph V. Bonventre, chief of BWH's Renal Division and Chief of BWH's Division of Biomedical Engineering.

This achievement shows that human kidney glomeruli made in vitro can connect to blood vessels after transplantation and grow to maturity.

Immunohistochemistry of paraffin - embedded human kidney tissue slide using 60004 -1-Ig (GAPDH Antibody) at dilution of 1:50 (under 10x lens)

Immunohistochemical of paraffin - embedded human kidney using 11708 -1-AP (SMN antibody) at dilution of 1:100 (under 10x lens)

An ear scaffold, left, provides the structure to grow human cells.A kidney stripped of cells, right, awaits an injection of human kidney cells, part of the process of engineering a new organ.

In the later stages of human kidney disease, when some physicians believe that truly low protein diets are advisable, some physicians and nutritionists attempt to get around the dangers of low protein by supplementing the patient's diet with amino acids that have been enzymatically oxidized into keto (C =O) amino acids.

The team is now attempting the same procedure using human kidneys, and also pig kidneys, which could be used to make scaffolds if there were a scarcity of human donors.

That is because «the human kidney is made, by design, to vary the accretion of salt based on the amount you take in,» explains Michael Alderman, an epidemiologist at the Albert Einstein College of Medicine and former president of the International Society of Hypertension.

Gather and Yun did this with cells derived from a human kidney, adding the DNA that codes for GFP.

Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity.

While the human kidney does have some capacity to repair itself after injury, it is not able to regenerate new nephrons.

The kidney structures also have the potential to facilitate further studies of how abnormalities occur as the human kidney develops in the uterus and to establish models of disease where they can be used to test new therapies.

The human kidney cell involved survived the experience, and though we are a long way from the laser eyes of Cyclops from the X-Men franchise, the achievement suggests that «living lasers» might be created inside live animals.

The data bring an understanding of human kidney development to a new level,» said Dr. McMahon.