Sentences with word «hydroxyurea»

Rather than calculating a standard dose of hydroxyurea based on patients» weight, researchers used a dose - escalation approach to determine the maximum tolerated dose for each of the 230 St. Jude patients enrolled in the study.

However, attempted clinical management includes treatment with hydroxyurea and dexamethasone.

Although the cancer drug hydroxyurea is prescribed to some sufferers, it is not always effective and increases the risk of infection.

Jeremie Estepp, MD, said the papers» findings underscore the need to improve and expand access to hydroxyurea in the U.S. and internationally.

The findings should help settle the debate about how to optimize hydroxyurea for treatment of sickle cell disease in young people.

«These results also confirm that the benefits of hydroxyurea persist.

Patients treated with a drug called hydroxyurea produce «healthier» red cells, suffer fewer painful attacks and need fewer transfusions, they say.

How hydroxyurea works is not clear, although researchers know that it interferes with the working of DNA.

The committee also strongly advocates for prescribing hydroxyurea, an oral medication taken once daily that has become the standard of care.

«These national guidelines are directed not just to hematologists but to all medical practitioners who might encounter sickle cell disease patients, to inform them about hydroxyurea and how to best offer general medical care to them,» Dr. Buchanan said.

«This is because while both cell types show hydroxyurea - induced gene expression, collision with replication occurs differentially because replication forks have progressed to different extent in these cells,» said Feng.

Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease.

Despite hydroxyurea's proven benefits, the optimal dosing strategy for the drug has remained controversial.

«A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy.»

Also lacking has been evidence of overall improved patient outcomes if hydroxyurea is used to increase blood levels of fetal hemoglobin to more than 20 percent.

St. Jude Children's Research Hospital researchers report that maximizing the dose of hydroxyurea increased levels of fetal hemoglobin and reduced the odds of hospitalizations for young sickle cell anemia patients

In an attempt to stave off Arya's decline until something better came along, her parents and doctors decided to try hydroxyurea, an old cancer drug that had been shown to boost levels of the neuron - nourishing protein somewhat in preliminary lab tests.

Currently available treatments including hydroxyurea, which is the only FDA approved drug for SCA, and hemopoietic stem cell transplantation all have significant limitations, so the search for new therapeutic options continues.

Peterson ME, Randolph JF: Diagnosis of canine primary polycythemia and management with hydroxyurea.

Estepp said the findings also underscore the need to improve and expand access to hydroxyurea in the U.S. and internationally.

St. Jude Children's Research Hospital investigators have shown that using the drug hydroxyurea to boost average fetal hemoglobin levels above 20 percent in children and teenagers with sickle cell anemia was associated with at least a two-fold reduction in hospitalization for any reason.

For this study, patients received a starting dose of hydroxyurea that was escalated in a stepwise manner until patients reached a predetermined maximum dose (either 35 milligrams per kilogram daily or 2,000 milligrams daily) or experienced mild neutropenia.

In an accompanying editorial, Debra L. Weiner and Carlo Brugnara of Harvard Medical School call for increased use of hydroxyurea.

The original study of hydroxyurea's effects, which was randomized, double - blind and tested for the placebo effect, took place between 1992 and 1995.

At the present time, hydroxyurea is the only Food and Drug Administration - approved medication that decreases the number of pain crises and episodes of acute chest syndrome.

Feng said that breakage patterns at different subsets of the hydroxyurea - induced genes were also observed in wild type cells and checkpoint - deficient mutant cells with unstable replication forks.

«Using the anti-cancer drug and a replication inhibitor, hydroxyurea, in the model organism Saccharomyces cerevisiae, we observed that double strand breaks preferentially occurred at hydroxyurea - induced genes,» said Feng.

Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide.

St. Jude pioneered the use of hydroxyurea to treat sickle cells in children.

More than half the patients received a hydroxyurea starting dose of 20 milligrams per kilogram.

«These results support a hydroxyurea dosing strategy designed to produce fetal hemoglobin levels that exceed 20 percent in an effort to decrease hospitalization of children with sickle cell disease,» Estepp said.

Previously published data from HUSTLE and other studies reported that hydroxyurea was safe, reduced stroke risk and improved spleen and kidney function.

Treatment involved three anti-cancer drugs — cisplatin, fluorouracil and hydroxyurea — and twice - a-day radiation therapy directed at the tumor bed for five days, followed by nine days of rest.

By this point Arya was losing ability to control her neck muscles; the hydroxyurea wasn't working and was stopped.

Recently, drugs such as 5 - hydroxyurea have been used to treat meningiomas, but as yet there are no data on the efficacy of this approach.