Sentences with phrase «in obese mice»

New research has uncovered an enzyme inhibitor found to prevent and reverse the effects of diabetes in obese mice.

Researchers have created engineered proteins that lowered body weight, bloodstream insulin, and cholesterol levels in obese mice, rats, and primates.

They showed that in obese mice who had been fed a high - fat diet, tumor progression and dissemination outside the prostate is greater than in mice with normal body weight.

The researchers also studied the effect of switching off hunger neurons in obese mice.

The investigators observed that two common cancer - fighting drugs sparked significant weight loss in the obese mice, even though the mice continued their excessive consumption of a high - fat diet.

They've also found that omega - 3s can help fight diabetes in obese mice, pointing the way to potential therapies in humans.

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E — BP2 expression.

In the study, the authors identified a monoclonal antibody to aP2 that lowered fasting blood glucose, increased insulin sensitivity, and lowered both fat mass and incidence of fatty liver in obese mouse models.

«We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage - mediated inflammation in obese mice,» said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine.

Meanwhile, Granier became interested in adiponectin receptors after a Japanese group showed that a small molecule could activate the receptors for to increase insulin sensitivity in an obese mouse model.

Soluble dietary fiber improves energy homeostasis in obese mice by remodeling the gut microbiota — Haiyuan Wang — Biochemical and Biophysical Research Communications

Handa, T., Yamaguchi, K., Sono, Y., and Yazawa, K. Effects of fenugreek seed extract in obese mice fed a high - fat diet.

Friedman's group was able to track down the mutation in the obese mice and found that it blocked production of a particular protein hormone, which they named leptin.

When tumor cells that no longer express CCR3 are implanted in the prostates of mice, tumor progression and dissemination are significantly reduced, especially in obese mice.

A drug that reverses the condition in obese mice could make it much easier to control the disease

Carrying excess fat does not contribute to a warmer body in obese mice, a new study on the insulating effects of fat finds.

«Vaccines fail to protect obese mice from severe influenza infections: Fu vaccines with adjuvants don't work as well in obese mice.»

In the new study, HSPH researchers first increased the levels of aP2 in normal, healthy mice to match the high blood aP2 levels seen in obese mice and humans.

CK2 activity is also heightened in obese mice, the team discovered, suggesting a link between obesity and the loss of brown fat.

«Understanding how the drug also enables crosstalk between fat cells and the liver in obese mice allows us to see more of the amlexanox picture — and also sheds light on communication between different tissues in the body.»

By comparing the behavior of XBP - 1s in the obese mice with that in lean, healthy ones, he discovered an inflammatory protein that modifies XBP - 1s in healthy animals so it can be shuttled into the nucleus.

The team also observed an increase in testicular inflammatory proteins in the obese mice.

Armed with two proven methods for activating targeted neurons at will — one optical, one chemical — the researchers were able to turn on the glutamate - releasing cells in obese mice.

The weight reduction observed in the obese mice was not attributable to trivial explanations, such as a decrease in dietary intake, increased energy expenditure or malabsorption.

«Inactivity in obese mice linked to a decreased motivation to move.»

This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals.

Compared to lean mice, osteoarthritis progressed much more quickly in the obese mice, with nearly all of their cartilage disappearing within 12 weeks of the tear.

The hepatic expression level is up - regulated in obese mice compared to lean animals (PubMed: 21987372).

Lean and diet - induced obese mice were used to characterize single - dose in vivo pharmacological effects of IRAB - A; multiple - dose IRAB - A effects were tested in obese mice.

CD36 - and GPR120 - mediated Ca2 + signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.

there is a 5-fold increase in number of insulin - secreting cells per islet in obese mice with high insulin secretion

The tests also revealed that exercise improved the thickness of bone, and that this effect was particularly pronounced in obese mice.

Moreover, leucine supplementation in obese mice increased NAD +, mitochondrial biogenesis, insulin sensitivity, and lipid disposal [107].

Because obesity is known to increase a woman's risk of endometrial cancer by 200 percent, a team of researchers led by oncologist Leena Hilakivi - Clarke of Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C., decided to examine the development of endometrial cancer in obese mice to that in non-obese mice.

Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K. Fast / Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.

Investigators in the lab of Alan Saltiel, the Mary Sue Coleman Director of U-M's Life Sciences Institute, had previously discovered that this drug, which had been used in the treatment of asthma, also has the ability to cause weight loss and improve diabetes in obese mice.

Pini M, Rhodes DH, Castellanos KJ, Cabay RJ, Grady EF, Fantuzzi G. Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice.

Source: Shang H, Sun J, Chen YQ (2016) Clostridium Butyricum CGMCC0313.1 Modulates Lipid Profile, Insulin Resistance and Colon Homeostasis in Obese Mice.

However, in obese mice with kidney disease, autophagy was suppressed and kidney cells became damaged.

The inhibitor we discovered successfully relieved the symptoms of type II diabetes in obese mice and not only elevated their insulin levels but promoted healthy insulin signaling within the blood.»

In obese mice, activation of this receptor stimulates orexin A release.

New study shows that in obese mice a hormone secreted by fat cells goes undetected and the regulation of appetite is thrown off; findings could trigger treatment

Now researchers have found that tissue surrounding breast cells is «stiffer» in obese mice and women, and that this tissue difference in the rodents spurs the growth of cancer cells.

The investigators found that in obese mice, physical inactivity results from altered dopamine receptors rather than excess body weight.

Research carried out at the University of California (UC), Davis and the University of Barcelona has uncovered an enzyme inhibitor found to prevent and reverse the effects of diabetes in obese mice.