Sentences with phrase «inflammatory pathways»

His research focuses on understanding the role of inflammation in retinal degenerative diseases and seeks to target inflammatory pathways in these diseases using gene therapy.

The trial also recorded fewer cases of lung cancer in those on the treatment, consistent with basic research findings hinting that the same inflammatory pathway may initiate or spur tumor growth.

I wonder if some of them could push some of those more inflammatory pathways.

Such high carbohydrate levels put a strain on digestion and absorption, affect insulin metabolism, and trigger inflammatory pathways.

The compound also appears to be effective in small amounts, potentially reducing the toxicity that has been shown in biological compounds targeting the same inflammatory pathway.

Another key study also found that curcumin blocked inflammatory pathways, effectively preventing the launch of a protein that triggers swelling and pain.

Autoimmune drugs inhibit inflammatory pathways or reduce the activity of immune cells.

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

«Sugars in Western diets increase risk for breast cancer tumors and metastasis: Study in mice points to sugar's impact on inflammatory pathways as culprit.»

Gladstone scientists identify inflammatory pathways as a potential therapeutic target for frontotemporal dementia

The stressor also activates key inflammatory pathways in peripheral blood cells and increases in levels of pro-inflammatory cytokines.

«Blood sugar fluctuations, whether someone misses a meal or someone eats too much, actually trigger the autoimmune inflammatory pathway.

As IL - 6 is also involved in immune inflammatory pathways, Muotri suspects a link between autism and in utero exposure to — perhaps not even infection with — Zika virus.

«Because inflammatory pathways influence nearly all diseases in humans and animals, including HIV infection and cancers, identification of SAMHD1 as an inhibitor of immunity may have far - reaching implications in biomedical research,» he said.

Huntington's monkeys also show levels of inflammatory markers (cytokines and inflammatory pathway genes) in their blood that is greater than in controls.

To the Penn scientists, the findings indicate that blocking the CCL2 - CCR2 inflammatory pathway in pancreatic cancer is worth investigating as an add - on to radiation therapy, not just to chemotherapy.

Hear how inflammatory pathways, commonly upregulated in human malignancies, represent major determinants of tumor fate

A novel inflammatory pathway mediating rapid hepcidin - independent hypoferremia.

«It's one of the first studies to modulate inflammatory pathways [to] show effects on longevity.»

Capsaicin makes up about 12 percent of the pepper and is capable of intercepting inflammatory pathways and producing a numbing effect.

When an acute injury has taken place, the cellular inflammatory pathways signal the body to send red and white blood cells to the injured area in order for healing to take place.

Stress induces a complex inflammatory pathway, involving the the nervous and endocrine systems, resulting in urinary bladder inflammation in the cat.

Recent theorizing has suggested that feeling sick and acting sick are adaptive elements in the response to a variety of ailments (cf. Hart, 1988; Dantzer and Kelley, 2007), and that upregulated inflammatory pathways may play an important signaling role that facilitates the perception of being sick and organizes illness - related behavior.

These medications are very effective and acts by blocking inflammatory pathways that lead to the production of destructive molecules (prostaglandins) and subsequent pain.

The innate acids in the extract suppress inflammatory pathways and repair damaged tissue.

We needed to simultaneously measure multiple cytokines in order to evaluate networks of inflammatory pathways.»

But these housekeeping cells have an additional role — they switch on inflammatory pathways.

Called the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) and funded by the drug giant Novartis, the trial also found fewer cases of lung cancer in those on the treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth of such tumors.

However, in the process, microglia turn on inflammatory pathways in the brain, which can cause further damage.

A 2006 study also found that a turmeric extract composed of curcuminoids (curcumin is the most investigated curcuminoid) blocked inflammatory pathways, effectively preventing the launch of a protein that triggers swelling and pain.4

Depression and all of its relatives are manifestations of glitches in the immune system and inflammatory pathways — not a neurochemical deficiency disorder.

The findings, which appear in the journal Frontiers in Molecular Neuroscience, found that most of the genes perturbed in brains from both diseases are related to the same immune response and inflammatory pathways.

In their previous work, also published in the Journal of Biological Chemistry Sept. 23, Heller's group found that the inflammatory pathway involving the two proteins begins with interleukin 4 (IL - 4), an immune system chemical that passes through a protein named IRS - 2 before activating the M2 cells.

By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last week.

That «shut down almost all of the inflammatory pathways,» Olefsky says.

Many of the genes identified by Dr. Papapanou and his team are implicated in immune and inflammatory pathways, confirming laboratory and clinical observations of the development of periodontal disease.

They found that the compound reduces levels of a key protein — known as IkappaBzeta — in the IL - 17 inflammatory pathway.

The compound suppresses an inflammatory pathway that is overactive in many autoimmune diseases, suggesting that it may be effective against multiple sclerosis, rheumatoid arthritis, lupus and other autoimmune diseases as well as psoriasis.

Knowing that inflammation improves insulin signaling rather than hindering it could usher in a new era for treatment of type 2 diabetes, one that targets molecules in the inflammatory pathway.

New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells.

«Targeting this inflammatory pathway with drugs or antibodies could be a new therapeutic strategy to treat worm infections and the associated pathology,» said Meera Nair, an assistant professor of biomedical sciences in the UC Riverside School of Medicine, whose laboratory made the discovery.

«We have found steroids also suppress inflammation by upregulating IRAK - M, a key negative regulator of inflammatory pathways,» Li said.

They revealed that dimethyl itaconate inhibits an inflammatory pathway called IL - 17.