Sentences with phrase «microarray analyses»
"Microarray analyses" refers to a way of studying genes and how they work, by looking at many genes at the same time on a tiny device called a microarray. This helps scientists understand which genes are active and how they work together in different conditions or diseases. Full definition
Microbial pathogens induce specific host responses or «RNA biosignatures» that can be identified using microarray analyses of blood leukocytes (white cells).
sciencedaily.com
Finally, the researchers used microarray analysis to investigate the gene expression and molecular pathways in the muscles of DS mice.
There were numerous altered pathways in DS muscle revealed by microarray analysis including the breakdown of proteins, metabolism of glucose and fat, and neuromuscular transmission.
Apart from science and engineering, bioinformatics is a vital tool in microarray analysis due to the vast amounts of data that are generated from a microarray experiment.
They employed whole genome microarray analysis to perform sample - matched transcriptome analyses.
Other labs have used DNA microarray analysis to characterize gene expression changes in this model.
Methods: By applying whole - genome oligonucleotide microarray analysis of D. vulgaris and high - efficiency capillary liquid chromatography - tandem mass spectrometry (LC - MS / MS), the group has investigated D. vulgaris grown on various electron donors or under stress conditions.
Microarray Analysis Confirms the Specificity of a Chlamydomonas reinhardtii Chloroplast RNA Stability Mutant
(2005) Whole Retinal Microarray Analysis of DBA / 2J Mice: A Model for Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 48).
To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.
A deep global analysis of the gut microbiota composition was done by phylogenetic microarray analysis using a Human Intestinal Tract Chip (HITChip), an analytical device designed specifically for studying gut bacteria.
MicroRNA expression profiling was determined by miRNA microarray analysis by using the human miRNA chip (LC Science, miRBase version 14.0).
In the current study, sets of a priori, user - defined functionally related genes were input into GSEA as well as normalized gene expression data from both control versus hypoxia and control versus recovery microarray analyses.
Antibody microarray analysis holds promise for increasing accuracy of breast cancer screening
To further test the quality of the resulting RNAs, the researchers performed replicate microarray analyses.
Proteomic analysis to profile protein abundance resulted in the identification and relative quantification for 912 proteins with two or more unique peptides and 86 proteins with significant abundance changes after treatment with the neurotoxins, while microarray analyses to profile gene expression revealed 181 genes with significant changes in mRNA after treatment.
Demonstration of loss of heterozygosity by single - nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection.
Hands - on knowledge of bioinformatics and microarray analysis software, cloning, and plasmid preparation will be considered a plus.
Innovative Affymetrix products, tools, and resources that help advance the work of researchers via microarray analysis.
In the new studies, scientists supported by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) tested a different approach, called microarray analysis.
Finally, RNA samples were prepared following the same procedure and subsequent microarray analyses were performed in a central facility using Affymetrix Mouse 430 v. 2 arrays.
41) Chari R, Lockwood WW, Coe BP, Chu A, Macey D, Thomson A, Davies JJ, MacAulay C, Lam WL (2006) SIGMA: a system for integrative genomic microarray analysis of cancer genomes.
Antibody Cross-Reactivity Testing Using the HuProt ™ Human Proteome Microarray Analysis of several commercially available antibodies against nearly 75 % of the human proteome.
Microarray analysis yielded results in 87 % of the stillbirths, compared to 70 % for karyotype analysis.
The total RNA from the adipocytes was isolated and carried out GeneChip microarray analysis.
He is using a new microarray analysis technology that assesses more then 23,000 genes.
Working on microarray analysis of age - related genes and development of molecular markers.Experienced on the studies of homologous relationship of ear - differentiation and morphological characteristics with long day - length and vernalization treatment in barley.
Stephen W. Scherer, Ph.D., of the Hospital for Sick Children, Toronto, and colleagues performed chromosomal microarray analysis (CMA) and whole - exome sequencing (WES) in a group of 258 unrelated children with ASD to determine the molecular diagnostic yield (the percentage of subjects with a genetic alteration [mutation] that may contribute to the features of autism spectrum disorder) of these tests.
Microarray analyses reveal that plant mutagenesis may induce more transcriptomic changes than transgene insertion.
This will be achieved by exposing the coral to seawater with high calcium concentrations to induce an alteration in gene expression profiles, identified using a DNA microarray analysis.
The immunopurification (IP) of Argonaute (Ago), a central component of the RISC in the human and mouse, followed by microarray analyses (Ago IP / microarray method) makes it possible to isolate any Ago - associated miRNAs and mRNAs without relying on the mechanism of regulation (i.e. mRNA decay or translational suppression), or sequence conservation, enabling a comprehensive identification of the miRNA - target genes in an unbiased manner.
«Optimization of RNA isolation from the archaebacterium Methanosarcina barkeri and validation for oligonucleotide microarray analysis.»
Parallel whole - genome microarray analysis was used to determine the transcriptome in matched samples.
Recently, Dr. Wapner led a multicenter study evaluating the accuracy, efficacy, and clinical advantages of prenatal diagnosis using microarray analysis.
We also performed microarray analysis of PyMT - Slc6a14 + / + and PyMT - Slc6a14 − / − mammary tumours to evaluate the expression of amino acid transporters without any biased preconception of the identity of the transporters that might be subject to changes in expression in association with Slc6a14 deletion.
While changes in the expression of several hundred genes were detected by microarray analyses, in the study by D'Mello and colleagues over 4,000 genes displayed significantly altered expression.
However, microarray analysis is only capable of measuring the status of known transcripts, and expression of low - abundance mRNAs is often not detected by the hybridization - based approach.
The foil - based measuring chip uses the microarray analysis platform MCR of the Munich company GWK GmbH.
Eager to sort through the pile of curriculum vitae's on his desk, Rudnicki is particularly looking for molecular geneticists working on different stem cell systems; scientists with genomics bents like proteomics, microarray analysis, and bioinformatics; and a couple of clinician scientists.
Finally, a microarray analysis found that when a clone grew to two cells, 2700 messenger RNAs — indicators of various protein levels — were either over - or underexpressed.
The researchers then used microarray analysis and pre-clinical animal assays to identify two predominant glioblastoma subtypes, proneural and mesenchymal.
The use of two newer genetic testing technologies (chromosomal microarray analysis and whole - exome sequencing) among children with autism spectrum disorder may help identify genetic mutations potentially linked to the disorder, according to a study in the September 1 issue of JAMA.
«We tried to do a thorough study,» Scherer says, «so that we could convince people to do a microarray analysis as part of their workup.»