Sentences with phrase «nuclear factor»

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) shows that a molecule called nuclear factor kappa B (NF - kB) helps cancer cells by suppressing the immune system's ability to detect and destroy them.

Osteoblasts modulate osteoclast activity through secretion of the TNF family member RANKL (receptor activator of nuclear factor κB ligand).

It does so by reducing the thermostat for inflammation called nuclear factor kappa beta.

Sulphorahane in broccoli blocks the aflatoxin which activates Nuclear Factor Kappa Beta in our cells.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and for controlling the expression of liver - specific genes, and it is associated with several critical metabolic pathways (Gonzalez 2008).

It seems that saturated fats affect systemic inflammation through inducing nuclear factor κB activation and expression of Cox - 2 through Toll - like receptor 4 (35).

One particularly bad guy in high amounts is the inflammatory nuclear factor kappa B, or NF - kB for short.

(2,3) Statin drugs can help with all this inflammation by down regulating Nuclear Factor Kappa Beta (NF - κ B), the master controller of the inflammatory response.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

Protein Kinase Casein Kinase 2 Mediates Inhibitor - κB Kinase and Aberrant Nuclear Factor - κB Activation by Serum Factor (s) in Head and Neck Squamous Carcinoma Cells

Cucurmin fights inflammation, protecting the cells of the body from oxidative stress caused by free radicals, and inflammation, mainly due to the inhibition of nuclear factor KB.

Activation of nuclear factor κ - light - chain - enhancer of activated B cells (NFκB) proceeds through multiple pathways involving tumor necrosis factor receptor 1 (TNF - R1) and pathogen - recognition receptors, such as Toll - like receptors (TLRs)(Orlowski and Baldwin, 2002; Madrid and Baldwin, 2003; Hayden and Ghosh, 2004) and nucleotide - binding oligomerization domain - containing protein 2 (NOD2), an intracellular pattern - recognition receptor.

Now, a team of researchers at the La Jolla Institute for Allergy and Immunology report that the shift is masterminded in part by NFAT, short for Nuclear Factor of Activated T cells, and best known for its crucial role in getting CD8 T cells battle - ready.

Over-activation of the inflammatory protein nuclear factor κB (NF - κB) in the brain region leads to a number of aging - related changes in mice, from cognitive decline to muscle weakness.

As we've discussed, curcumin quells inflammation through nuclear factor - KB inhibition, but its potent antioxidant capacity can also protect the skin from age - inducing free radical damage.

Scientists already knew that steroids suppress inflammation by directly targeting nuclear factor - κB (NF - κB), a master regulator of pro-inflammatory mediators.

IFN - regulatory factors (IRFs) bind PRDI and PRDIII (which are IFN - stimulated response elements, ISREs), whereas nuclear factor - κB and activator protein 1 (AP1) bind PRDII and PRDIV, respectively.

Targeted disruption of nuclear factor erythroid - derived 2 - like 1 in osteoblasts reduces bone size and bone formation in mice.

For example, an ATPase - and / or helicase - dependent mechanism is essential for RNA helicase A — mediated transactivation function (41) and the functional interaction with nuclear factor κB (42).

Ma and colleagues were able to show that rapid production of A20 protected mice from the damaging effects of TNF by inhibiting that substance's ability to activate a protein within cells known as nuclear factor KB.

High - glycemic index carbohydrate increases nuclear factor - κB activation in mononuclear cells of young, lean healthy subjects

Curcumin is known to inhibit inflammation by suppressing nuclear factor κB (NF - kB), a protein complex responsible for creating cytokines (some of which are responsible for pain responses), restricting various activators of NF - kB as well as stemming its expression.

One of the most important molecular sergeants is a protein called nuclear factor - kappa B (NF - kB), which can order the production of scores of defensive proteins.

Here is a list of widely available Botanicals which exert anti-inflammatory effect by down regulating Nuclear Factor Kappa Beta (NF - κ B).

The researchers found that patients from MODY3 families had one of several different mutations in the gene for hepatocyte nuclear factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the gene.

Receptor - interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked to the pathogen pathway that activates nuclear factor κ - light - chain - enhancer of activated B cells (NFκB) and autophagic activation.

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Pine bark extract also normalizes immune response by inhibiting Nuclear Factor - Kappa B.

It works by activating the inflammatory nuclear factor kappa B (NF - kB for short), which binds to your DNA and triggers a number of inflammatory cascades throughout the body.

In animal studies, activation of nuclear factor - kappa B (NF - kB); activation of inducible nitric oxide synthase (iNOS), and cyclooxygenase - 2 (COX - 2); and formation of malondialdehyde (MDA) have all be shown to get reduced following consumption of either sweet potato or its color - containing extracts.

For the study, published online this month in Neuron, researchers examined a protein involved in transcriptional regulation, called nuclear factor - kappa B (NF - κB), known to play a role in the neuroinflammatory response common in ALS.

Sulforaphane * 1, a phytochemical contained in broccoli sprouts at relatively high concentrations, has been known to exert effects of cancer prevention by activating a transcription factor, Nrf2 (nuclear factor (erythroid - derived 2)- like 2), which regulates the balance of oxidation — reduction in the cell, and by enhancing anti-oxidation ability of the body and detoxication of chemical compounds taken into the body.

For example, nuclear factor - kappa B (NF - kB) is a complex of proteins that acts as a master switch for turning inflammation genes on and for controlling cell death.

Working with cultures of respiratory tract cells, Elias's team found that the gene that codes for il - 6 is inactive unless a protein known as nf - kb (nuclear factor - kappa beta) attaches to the gene.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

«It was crucial to find out that synthesis of the anti-inflammatory cytokine IL - 10 by the B lymphocytes through the interaction with the protein «nuclear factor of activated T cells» (NFATc1), a transcription factor, was reduced,» Matthias Goebeler puts the study's central result in a nutshell.

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

A conserved domain of ∼ 300 amino acids that is found in the amino - terminal region of nuclear factor - κB (NF - κB)- family members.