A single
dose of a human antibody called ZIKV - 117 can protect mice from death after Zika infection — and shield mouse fetuses from the virus's damaging effects, researchers report November 7 in Nature.
A single dose
of a human antibody called ZIKV - 117 can shield mouse fetuses from the virus's damaging effects, researchers report online November 7 in Nature.
First, Dr. Shoyele included
part of a human antibody, immunoglobulin G (IgG), to cloak the particle from the immune system.
A novel study led by Mats Ohlin, Facility
Director of the Human Antibody Therapeutics Facility at the SciLifeLab Drug Discovery and Development Platform, has successfully tracked the mutations that occur during natural antibody maturation.
Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive
libraries of human antibody genes that could be screened quickly.»
Researchers have discovered that a
subset of human antibodies have catalytic activity against a particular antigen, breaking it down into smaller and less harmful fragments instead of trapping it for removal or destruction by other immune cells.
In one of the first molecular
studies of the human antibody response to yellow fever, Howard Hughes Medical Institute (HHMI) researchers and their colleagues have found the crucial bit of virus that...
Researchers fused part of a mouse - derived antibody to
part of a human antibody (creating chimeric mAbs) and grafted even smaller bits of mouse antibodies into human antibodies (humanized mAbs).