Sentences with phrase «of thalidomide»

He and his colleagues have studied the activity of thalidomide in developing limbs and have shown that developing blood vessels are a primary target of the drug.

FDA medical officer Frances Oldham Kelsey averted the tragedy of thalidomide birth defects in the United States

This was the hero who saved the United States from the tragedy of thalidomide, a drug often prescribed to pregnant women that could result in serious birth defects such as short, flipper - like arms and legs.

He was well known for playing a crucial role, as an expert witness, in winning compensation for the victims of thalidomide.

«There are no representative, controlled studies documenting the true spectrum of thalidomide injuries,» they write in the lawsuit.

Steingraber cites the disasters of thalidomide in the U.S. and methyl mercury in Japan (Minamata), and presses for a zero tolerance of all environmental contaminants.

«A universe of thalidomide related injuries has been thereby excluded from diagnosis.»

In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug.

Vargesson says his work does not confirm or deny that the plaintiffs» defects are the result of thalidomide.

Holmes also notes that the relative paucity of thalidomide births in the United States means that few researchers there can speak with authority on the drug's effects.

President John F. Kennedy honors FDA medical officer Frances Kelsey in 1962 for her work blocking U.S. approval of thalidomide.

Kelsey's wide - ranging experience in the 1930s,»40s and»50s would serve her well in the 1960s to recognize the threat of thalidomide.

While awaiting Merrell's response in early 1961, Kelsey read a letter in the British Medical Journal mentioning a possible side effect of thalidomide: peripheral neuritis, a painful tingling in the arms and feet.

Ever since the thalidomide birth - defects tragedy, animal testing has been enshrined in law worldwide, despite the irony that more animal testing would not have prevented the release of thalidomide, because the drug harms very few species.

If you look at the original work on the epidemiology of thalidomide [a morning - sickness drug that turned out to cause birth defects], there were specific time points where, if the woman was exposed, the baby had a high probability of having bona fide autism.

A new study published in the March 12 issue of Science has identified one primary target of thalidomide's teratogenicity (potential to cause fetal malformations)-- a protein called cereblon.

«Today, a number of thalidomide babies continue to be born each year reflecting regulatory insufficiency and widespread use under inadequate supervision,» the organization's Web site states.

They discovered that although high doses of thalidomide stop angiogenesis, lower doses actually fortify the blood vessels by spurring cell growth.

A pilot study of thalidomide, published in 2001, found the drug improved blood counts in some patients and enabled others to become transfusion - independent.

In West Germany, where the sleep - inducing drug was developed, the use of thalidomide by pregnant women was linked to many birth defects in their infants.

But the American and European research communities didn't regard randomized field trials as essential until the 1950s, when Jonas Salk discovered the polio vaccine and Sen. Estes Kefauver held hearings on the testing of thalidomide and other drugs.

Representing Grünenthal on the major product liability case involving a claim for damages in over $ 204m filed by the Spanish Association AVITE (Asociación de Víctimas de la Talidomida en España) representing 184 victims of thalidomide, for alleged damages caused in the 1960's for the administration of thalidomide.