Sentences with word «osteolysis»

These findings reveal a function for ABL kinases in the regulation of breast cancer bone metastasis and tumor - induced osteolysis in vivo.

Moreover, three - dimensional (3D) μCT reconstruction of the tibia revealed that mice injected with control cells had a significantly higher degree of osteolysis with a decreased ratio of bone volume to total volume compared to mice injected with ABL1 / ABL2 knockdown breast cancer cells (Fig. 4, E and F).

We demonstrated that ABL kinases promoted tumor - induced osteolysis in part through the osteoclast - activating cytokine IL - 6, increased serum concentrations of which are associated with poor clinical outcome in breast cancer patients (50).

The artwork appeared on the front cover of Applied Surface Science summarizes the benefits of a new bioceramic coating versus the commercially available Calcium Phosphate which develops microcracks during processing and may later cause osteolysis in load - bearing orthopedic implants.

Osteolysis occurs when particles from the implant seep into the surrounding tissue, prompting an inflammatory response which then destroys the bone around the implant.

These factors include chemokine (C - X-C motif) ligand 12 (CXCL12), a chemokine produced by bone marrow mesenchymal cells that functions as a chemoattractant and survival factor for cells bearing the chemokine (C - X-C motif) receptor 4 (CXCR4), and insulin - like growth factor 1 (IGF - 1), a factor that is stored in the bone matrix and released during osteolysis (28).

Joint fluid, tissue, and debris from implant wear can lodge in these spaces, causing eventual bone damage known as osteolysis.

Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response.

We found that allosteric inhibition of the ABL kinases effectively impaired breast cancer bone metastasis and blocked tumor - induced osteolysis in mouse models.

ABL kinases are required for tumor survival and tumor - induced osteolysis in the bone microenvironment.

There are also problems with the long - term performance of implants, such as release of debris from bioactive films which can potentially lead to osteolysis and chronic inflammation.»

Bone loss (osteolysis) was observed in many cases.

National data for England and Wales indicate that more than 2 % of procedures typically have to be repeated within three years, primarily because of osteolysis (75 % of cases).

Intravital microscopy of prostate cancer lesions in bone: kinetics of osteolysis and therapy response.

Calcification can be found at the center of the osteolysis giving it a characteristic appearance [8].

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

Two months before the recall, Stryker is reported to have put out a warning to medical professionals and affected parties over concern that the rubbing together of its parts could Adverse Local Tissue Reaction, including necrosis, metallosis, osteolysis, tumor - like formations, and pain serious enough to warrant revision surgery.