"Pancreatic tumors" refers to abnormal growths or masses that develop in the pancreas, which is an important organ responsible for producing enzymes and hormones. These growths can be benign (non-cancerous) or malignant (cancerous).
Full definition
When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells
in pancreatic tumor tissue, as well as a slowing of tumor growth.
«Innovative therapy strategy for pancreatic cancer uses engineered exosomes targeting mutated KRAS gene: Study demonstrates that «iExosomes» shut down growth
of pancreatic tumors in mice.»
Funded by the UK charity, Pancreatic Cancer Research Fund, the UCL team, led by professor Stephen Neidle, conducted a small - scale trial, treating two groups of eight mice
with pancreatic tumors with different doses of MM41 twice a week for 40 days (12 doses).
Recently, Ziaie and his team tested the device by implanting it
into pancreatic tumors in mice and were able to show a decrease in interstitial tumor pressure following administration of an angiogenic inhibitor.
But CCN1 does something extra when it's secreted
by pancreatic tumor cells as opposed to regular cells.
Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by
pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.
As pancreatic tumors grow and evolve, they collect LINE - 1 insertions, Burns and colleagues reported in Nature Medicine in 2015.
Previous research has shown that the signals coming from surrounding stromal cells include both supportive signals — which help
pancreatic tumors grow — and suppressive signals — which try to fight the cancer.
Because pancreatic tumors are often resistant to chemotherapy or radiotherapy, «the only hope is that we can remove it surgically» at an early stage, says Mark Bloomston, an associate professor in the Division of Surgical Oncology at The Ohio State University Medical Center in Columbus.
In a 2011 vaccine trial of patients whose
primary pancreatic tumors were surgically removed, «we found antibodies against annexin A2 in those who had received the vaccine and who also had demonstrated long - term, disease - free survival after receiving the vaccines,» explains Zheng.
Bottom Line: Bacterial load was significantly higher in
pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.
Our researchers have identified a bacterial - based therapy for
attacking pancreatic tumors, offering hope in the fight against one of the deadliest cancers.
On the clinical side, Dr. Smith particularly enjoys the challenges of endocrine surgery (adrenal tumor removal,
pancreatic tumor removal, etc.), as well as urinary tract and liver shunt surgeries.
In a recent study, working with a team of researchers, Danino demonstrated that bacteria in
pancreatic tumors degrade a chemotherapy drug — Gemcitabine — most commonly used to treat patients who have pancreatic cancer.
«Our studies suggest that exosomes exhibit a superior ability to deliver siRNA molecules and suppress
aggressive pancreatic tumor growth when compared to liposomes,» said LeBleu.
Studies in recent years by Beatty's laboratory and others have pointed to one potential source of this treatment resistance:
Pancreatic tumors tend to surround themselves with a protective «microenvironment.»
«We're still trying to figure out why these anti-tumor T - cells don't go into
pancreatic tumors like they do for other malignancies,» Beatty said.
Researchers at the University of Cincinnati (UC) College of Medicine have shown that a new targeted treatment could benefit patients with
certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage — a direct result of the tumor.
Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can
block pancreatic tumor formation and recurrence after radiotherapy.
Stanger and Maddipati tested the hunch that clusters of cells of different genetic makeup were better at establishing secondary tumors and found that a significant fraction of metastases involve seeding by more than one type of tumor cell during the natural course of
pancreatic tumor progression.
Exploiting the clarity and intensity of fluorescence, postdoctoral fellow Dr. Ozhan Ocal in Dr. Wilkie's group was able to represent images of pancreatic Rgs16 expression, and hence all the stages of
pancreatic tumor development, quantitatively.
When mice
bearing pancreatic tumors were injected with an antibody that prevents galectin - 9 from docking into dectin - 1, they developed M1 macrophages, which sent signals that dramatically increased the number of T cells capable of attacking the cancer cells.
Drs. Snigdha and Sushanta Banerjee, Ph.D., a husband and wife research team at the Kansas City VA Medical Center, are working towards cutting off the growth of
pancreatic tumors before they can metastasize throughout the body.
Now, Salk scientists have pinned down how signals from this microenvironment
encourage pancreatic tumors to grow by altering their metabolism.
In general, Metz said
neuroendocrine pancreatic tumors are a relief «because patients stick around for a long time and we can use various modalities to treat them.
Now, new research by CRI postdoctoral researcher Ingunn Stromnes, Ph.D., suggests why:
pancreatic tumors wrap themselves in a defense cloak that protects them from an immune attack.
LA JOLLA — A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells
shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible to therapeutic drugs.
EUS is a minimally invasive procedure used to diagnose and manage a wide range of gastrointestinal cancers and pre-cancerous lesions,
including pancreatic tumors.
Called granulocyte - myeloid - derived suppressor cells (Gr - MDSCs), these cells increased in number at precisely the same time that
pancreatic tumors became more aggressively invasive.
2000 Johns Hopkins Cancer Center researchers develop a pancreatic cancer vaccine and prove it activates immune cells
against pancreatic tumor cells.
This Dream Team also developed a new method of
identifying pancreatic tumors that have spread to the brain and liver, which could significantly aid in diagnosis.
Comparative Motion and Dosimetric Analysis of Organs at Risk
Near Pancreatic Tumors Treated with Stereotactic Body Radiation Therapy with and without Abdominal Compression Using 4DCT Data Sets