Sentences with phrase «potential therapeutic targets»
This has prevented the identification of potential therapeutic targets for clinical intervention.
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However, a great deal of basic research is still required to understand the molecular bases of rare diseases and identify potential therapeutic targets.
This finding may lead to new potential therapeutic targets.
Together, these findings represent potential therapeutic targets that could help to treat and prevent infection.
Once identified, these become potential therapeutic targets, as new drugs could be designed specifically to activate or inhibit them.
Potential therapeutic target molecules in these pathways will be highlighted in the conference.
While much work remains, Mei and his colleagues believe the work published in the journal Nature Neuroscience provides new insight into the critical regulation of neurotransmitters that enable neurons to take action as well as potential therapeutic targets for one day helping individuals with intellectual disabilities.
The research approaches primarily investigate signaling pathways as potential therapeutic targets in tumor cells and the development of novel agents, either alone or in rationally designed combinations.
«Dr. Gregg and his team are building the sandbox that we can explore together in order to expand our library of potential therapeutic targets for diseases like cancer.»
«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»
«Neuroscientists are using these new gene - editing and molecular tools to develop potential therapeutic targets across multiple disease fronts.»
Luke Tain: «Given the high evolutionarily conservation of IIS and TOR function, our results implicate potential therapeutic targets to improve sleep quality in humans.
«New color blindness cause identified: Finding suggests potential therapeutic targets.»
Two current publications highlight the power of such an unbiased genetic screen to identify potential therapeutic targets from the protein kinome for Ewing's sarcoma and neuroblastoma through the use of RNAi profiling combined with real - time, label - free technology.
They will also map the regulatory machinery for stress granules, to seek potential therapeutic targets.
Several potential therapeutic targets have been identified by our approach, including modulation of NMDA receptor expression and signaling, which until now have only been shown to play a role in responding to ischemia.
These findings may help pinpoint potential therapeutic targets for treating diseases associated with C. difficile, such as gastroenteritis.
YEATS protein potential therapeutic target for cancer (10/23/2014) The Shi lab has found a new protein reader of modified proteins.
Our lab is focused on delineating the mechanisms underlying these key GSC tumorigenic properties with a long - term goal of uncovering potential therapeutic targets.
to promote therapeutic innovation through the validation of candidate genes as potential therapeutic targets and to determine their effects in referenced model organisms, particularly so - called humanized mice, and if essential the non-human primate model.
Xiang - Dong Fu, PhD, professor of cellular and molecular medicine and member of the UCSD Institute of Genomic Medicine, in collaboration with Michael G. Rosenfeld, MD, will use cutting - edge genomic and RNA - based approaches to help identify new potential therapeutic targets.
Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.
Writing in Cell, the researchers from the University of Cambridge and University of Toronto also identify potential therapeutic targets for these currently incurable diseases.
«Potential therapeutic target for deadly brain cancer.»
A map of which genes that are switched on or off in tumour cells of uterine cancer, has been created by researchers, identifying a range of potential therapeutic targets
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five - year survival rate.
NIBR is similar to an academic setting, Sabatos - Peyton says, because scientists do in - depth, foundational research on a topic, for example the validity of a potential therapeutic target.
Hyperactivity of the innate immune system has been identified as a potential therapeutic target for HD.
These observations suggest that YAP1 may be a potential therapeutic target.
«Excitement in the brown fat field has risen significantly over last few years because its energy - burning nature makes it a potential therapeutic target against obesity and diabetes,» said Dr Lee.
Our study points to potential therapeutic targets that could be inhibited to halt tumor cell movement,» says principal investigator Cynthia Reinhart - King, PhD.
A study published in Journal of Investigative Dermatology has identified a potential therapeutic target for the treatment of psoriasis, a chronic inflammatory disease of the skin that affects up to a 2 % of the population and which has still no cure.
Dr Selth says miR - 194 also represents a potential therapeutic target.
The results show TREX2 as a potential therapeutic target to tackle this disease with a different and more focused strategy.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
Their report in the August 28 issue of Cell also suggests that a cell adhesion protein binding CTC clusters together is a potential therapeutic target.
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
The elucidation of this sequence also revealed two potential therapeutic targets: ANT2 and HIF - 1alpha.
UT Southwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer.
Further investigation uncovered CHD1's role as vital to PTEN signaling, and as a potential therapeutic target in prostate and breast cancers with PTEN gene loss.
This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.
This discovery provides a new potential therapeutic target.
More research is needed to learn about ways in which the genes contribute to development of Tourette syndrome and whether they may be potential therapeutic targets.
We need to broaden our potential therapeutic targets.
Jackson Laboratory research team led by Professor Lenny Shultz, Ph.D., reports that a protein involved in wound healing and tumor growth could be a potential therapeutic target.
Therefore, BCAR4 may be a potential therapeutic target for cervical cancers with this alteration.
Findings from this study provide a potential therapeutic target and offer the possibility for developing a treatment.
The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.
Given their ability to regulate EGFR signaling in parallel with metalloproteases, iRhoms can be potential therapeutic targets in impaired wound healing and cancer.»