Sentences with phrase «preclinical work»
"Preclinical work" refers to the preliminary research and testing that occurs before clinical trials in humans. It involves studying the effectiveness and safety of new medical treatments or drugs through laboratory experiments and animal studies. Full definition
«She had worked at Immunex's law department, was one of the co-discoverers of Enbrel and was listed on multiple original Immunex patents, and had been involved in preclinical work on compound discovery,» says Ruth Kunath, who managed Vulcan's biotech portfolio from 1992 to 2003 and hired Beckmann.
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Moderna's preclinical work for mRNA - 1325 was funded through a grant from the Defense Advanced Research Projects Agency (DARPA).
Gatenholm says further preclinical work needs to be done before moving on to human trials.
«There's a lot of preclinical work with a lot of potential.
We've done a lot of preclinical work in mouse models showing that it works much better when you can combine it with other things, like vaccines.
Further preclinical work will be needed to use the herpes - loaded stem cells for breast, lung and skin cancer tumors that metastasize to the brain.
Preclinical work on the vaccine is being conducted with long - term HIV vaccine collaborators at the Beth Israel Deaconess Medical Center, Harvard Medical School.
The study, which lays the foundation for future preclinical work, appears June 14 in Stem Cell Reports, a publication of the International Society for Stem Cell Researchers.
Dr Christodoulides and his team will continue preclinical work with the potential vaccine with an aim of taking it to Phase 1 trials.
«Sometimes pharmaceutical companies can't replicate preclinical work,» says Bushnell, who came to NCCAM to develop a pain research program.
In a second talk at the meeting, stem cell researcher Masayo Takahashi of the RIKEN Center for Developmental Biology in Kobe reported on progress in her group's preclinical work targeting wet - type age - related macular degeneration (AMD).
We are currently completing preclinical work required by regulators and plan to begin the pivotal trials in the U.S. and Europe in the first quarter of 2018.
Russell Kern, chief scientific officer of the International Stem Cell Corporation in Carlsbad, California, which is providing the cells for and managing the Australian trial, says that in preclinical work, 97 % of them became dopamine - releasing cells.
Your experience reminds me of preclinical work.
Some retrospective studies and preclinical work have indicated that it might also lower a person's risk of cancer, though at least one clinical trial wasn't able to show that it had any protective effect on esophageal cancer.
Researchers believed that galeterone could be effective against CRPC because it disrupts the androgen receptor signalling pathways that are involved in the cancer, and preclinical work has shown it is active against the AR - V7 variant.
«Although this is preclinical work, the strategy warrants further investigation because it holds promise as a simple, economical way to overcome the major limitation of current flu vaccination strategies and may provide broad protection against seasonal and pandemic influenza,» added Elliott.
«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.
Cancer Research UK's investment will support two of the three clinical trials, preclinical work, assay development, biomarker work and the huge amount of molecular sequencing.
The preclinical work applied the same type of stimulation to restore and facilitate memory in animal models using the MIMO system, which was developed at USC.
«It's exciting to see our preclinical work moving into the clinic,» Richer says.
The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.
Faulty mitochondria contribute to a range of diseases and a research group working towards the use of mitochondrial donation techniques for women at risk of passing on those diseases to their children have described their preclinical work in the journal Nature.
«The preclinical work being done by the McDonald lab has been extremely informative in helping us understand that Pexa - Vec is working like a vaccine to sensitize the immune system to attack cancer,» said James Burke, CMO of SillaJen Biotherapeutics.
Col. Nelson Michael, the WRAIR Zika program co-lead, said, «The preclinical work gives us early confidence that development of a protective Zika virus vaccine for humans is feasible.»
This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.
In parallel, we are going to finish the preclinical work for our modular mono - or multispecific targeting systems.
He had just finished his preclinical work at St. Bartholomew's and the Royal London Medical School when the 21 - year - old opted to complete a yearlong cellular pathology program at University College London (UCL) Medical School and earn his bachelor's degree.