Sentences with phrase «prognostic marker»

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

A research group headed by Gustavo Turecki, professor of psychiatry at McGill University in Montreal, Canada, recently used the platform to show that miRNAs can be used as prognostic markers for therapeutic responses to an antidepressant medication in patients with major depressive disorder (3).

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after multivariable adjustment.

Traditional prognostic markers based on tumor grade have proven unreliable for ependymomas.

«Cadherin - 22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,» said lead author Prof. Jim Uniacke, Department of Molecular and Cellular Biology.

Detection of miR - 34a inactivation may therefore represent a useful prognostic marker,» says Hermeking.

The researchers believe that they have identified a group of RNA molecules — known as long noncoding RNAs (lncRNAs)-- that hold the potential for serving as better prognostic markers for prostate cancer.

They explained that maintaining weight is a key prognostic marker in cystic fibrosis and nutritional failure is a serious problem in the disease.

While further studies are needed for clinical validation, he says, «Based on the known metabolism of sarcosine in cancer, we postulate that elevated 11C - sarcosine uptake is a negative prognostic marker and may potentially be useful to monitor mTORC1 - targeted cancer treatments.»

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

Using clinical samples we would like to create an immunoprofile of activated B cells and memory B cells that may provide prognostic markers for dengue immunity and / or immunopathology.

We demonstrated that the other MAP3K, MAP3K8, accumulates in high - grade ovarian carcinomas and is a new prognostic marker for these tumours.

Elevated CRP was an independent prognostic marker for overall survival among patients with delayed transplant (hazard ratio, 2.0; 95 % CI, 1.0 — 3.8; P =.045).

Finally, we ask whether the mechanical differences between normal and cancer cells can be used as diagnostic or prognostic markers of cancer progression.

«Using our new analytical method, our aim is now to identify new predictive, diagnostic and prognostic markers in tissues, as well as to understand disease processes.»

A randomized pilot trial of oral branched - chain amino acids in early cirrhosis: validation using prognostic markers for pre-liver transplant status.

Plasma levels of sNKG2D - L, and verexpression of ADAM10, correlate with disease progression and are prognostic marker in some hematologic malignancies, including Hodgkin lymphomas (HL).

CXCR4 is found to be a prognostic marker in many different cancers [22], including leukemia [23 - 27], breast [28, 29], lung [30, 31], prostate [32], ovarian [33] and colorectal cancers [34], where the SDF - 1 / CXCR4 axis plays an important role in cancer progression [22](Figure 3).

Even after inclusion of all these factors, sidedness remained an independent prognostic marker, with a hazard ratio of 1.392 (95 % CI, 1.032 — 1.878; P =.031).

«In the preplanned biomarker analysis, the expression of pSTAT3 detected by immunohistochemistry was both a prognostic marker and a predictive biomarker of benefit from napabucasin,» the researchers wrote.

In patients with metastatic breast cancer, our large multicenter study confirmed that CTC can be used as a prognostic marker and that dynamic early changes during chemotherapy are associated with the treatment outcome (Pierga, Ann Oncol 2012).

We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker.