Sentences with phrase «resistance to therapy»

Currently, if breast cancer cells develop resistance to these therapies, patients are usually treated with toxic chemotherapy agents that have significant side effects.

«Our primary question was not aimed at evaluating resistance to therapy, but we did end up there,» she said.

Unfortunately, almost all patients eventually develop resistance to this therapy, leaving doctors with no options to counteract the inevitable.

His area of interest is exploring the effects of tumor heterogeneity on relapse and resistance to therapies in sarcomas.

«Considering that frequent amplification of MET accounts for resistance to therapies now in development and to poor prognosis, not only in ovarian cancer but in other cancers too, our findings pinpoint an important new signaling hub, involving the role of FER in MET activation.

Unfortunately, cancer cells fight back by trying to fix the breaks through a toolkit of specialised armies, giving cancer resistance to therapy.

This high mortality is primarily caused by resistance to therapy and the diagnosis of ovarian cancer after it has already metastasized, which occurs in approximately 80 percent of patients.

C. Develop ways to overcome cancer's resistance to therapy Identify therapeutic targets to overcome drug resistance through studies that determine the mechanisms that lead cancer cells to become resistant to previously effective treatments.

Therefore, since there cases of resistant and aggressive melanoma phenotypes or resistance to therapy occurs during treatment targeted or invasive treatment should be considered.

It has been observed that Malignant melanoma tends to metastasize due to its aggressive capacity and also due to resistance to therapy [2].

Altieri and his colleagues have used biochemical and genetic approaches to study the role of survivin in apoptosis inhibition, and how this process enables aberrant cell viability in tumors, as well as resistance to therapy.

At the same time, the Trotman lab is exploring the genome alterations associated with metastatic disease and with resistance to therapy.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

«Unfortunately, we see some patients don't respond to these wonderfully new therapies and some patients that do respond initially eventually develop resistance to those therapies and so the tumor returns,» Bertagnolli says.

The Ignatius laboratory is interested in understanding the effects of tumor heterogeneity on relapse and resistance to therapies in Rhabdomyosarcoma and other sarcomas.

Whilst further study is needed, we are building evidence to show that genetic diversity in a bacterial infection or in a tumour being treated could lay the foundation for resistance to the therapy and affect how quickly resistance develops.»

«But it may be a foundation for parasites to evolve stronger degrees of resistance to these therapies, so we have to watch for increasing resistance very carefully.»

ADAR1 is known to promote cancer progression and resistance to therapy.

They have also discovered that a protein named Wnt5A promotes metastatic progression, resistance to therapy and poorer prognosis, and one of the ways in which it is regulated is by the anti-aging protein Klotho.

However, resistance to therapy might go beyond cancer mutations that usually alter the function of genes.

The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»

Resistance to therapy is inevitable.

«Our researchers were able to identify a change in a specific mark in the proteins that wrap the DNA — called histones — in such a way that makes repair much faster in cancer cells, increasing their resistance to therapy.»

Moreover, just as the stem cell niche plays a crucial role in the maintenance of stemness, many intra-microenvironmental connections and relationships between the microenvironment and the tumor play a crucial role in enriching the CSC subpopulation; as such, disrupting these relationships may be key to curbing their resistance to therapy.

The bioinformatics team uses sophisticated algorithms to elucidate markers of response and resistance to therapy, as well as determine how patients can be stratified appropriately for the most relevant therapies under study.»

Malignant melanoma is known to be a lethal disease due to its aggressive capacity for metastasis and resistance to therapy.

Desmoplastic stroma is a defining feature of pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, and contributes to tumor progression and resistance to therapy.

These cells often escape the reach of currently available cancer treatments, or even develop resistance to the therapies themselves.

The Department of Translational Research hosts 5 technological platforms (Genomics, Protein arrays, High - content screening, Experimental radiotherapy and Preclinical investigation), 4 labeled teams (resistance to therapy in breast cancers, translational pediatrics, angiogenesis, and immunotherapy) and 3 emergent teams (Circulating biomarkers, uveal melanoma, and new targets in triple negative breast cancers).

Meenhard Herlyn, D.V.M., D.Sc., developed a three - dimensional human skin reconstruct model that is instrumental in the study of melanoma biology and resistance to therapy.

In addition, since lung tumours commonly have hundreds of mutated genes, it is difficult to pinpoint those that are responsible for tumour growth and resistance to therapy, creating a clear bottleneck in the translation of laboratory findings to a clinical setting.

«The earlier we can carry out the sequencing the better chance of identifying the right therapy before they develop resistance to therapies we could predict wouldn't work.

«My project focuses on a protein called NRF2, which has been linked to resistance to therapy.