Sentences with word «rhabdomyosarcoma»
Diagnosis of rhabdomyosarcoma begins with a thorough health history and a comprehensive physical examination.
mottchildren.org
In another case a 4 - month old dog was affected with embryonal rhabdomyosarcoma of the trachea.
«The way we manage children with rhabdomyosarcoma today is based on what he did through all those years of tireless work in the Pediatric Oncology Group.
«A so - called «muscle» cancer is not really a muscle cancer: Pinpointing the cell type that turns malignant in rhabdomyosarcoma opens the path for better treatments.»
The Christina Renna Foundation donates over $ 30,000 for rhabdomyosarcoma research, and honors Associate Professor Chris Vakoc with its research award...
Research led by Mark Hatley, MD, PhD, of St. Jude Oncology, has shown that certain embryonal rhabdomyosarcoma tumors arise from early endothelial cells instead.
About 60 percent of rhabdomyosarcoma patients have tumors of the embryonal subtype, and about 25 percent have the alveolar subtype.
As noted in Part I of this article, γ - tocopherol is preferentially metabolized into γ - CEHC, and the latter compound has been observed to exert much stronger anti-proliferative activity than α - CEHC in prostate cancer cells and rhabdomyosarcoma cells.
Based on the results, St. Jude plans to expand biopsies to include recurrent rhabdomyosarcoma tumors and possibly other solid tumors.
Embryonal rhabdomyosarcoma included far more genomic alterations than alveolar subtype tumors.
In addition to research on rhabdomyosarcoma, the Ignatius laboratory has also generated new syngeneic zebrafish models of aggressive Malignant Nerve Sheath Tumors and hemangiosarcomas for which there are no effective treatments.
«Studies like the current one involving rhabdomyosarcoma are giving us a close - up look at the way cancer evolves in response to treatment,» said study co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequencing.
Research on mouse tumors resembling rhabdomyosarcoma, the most common soft tissue sarcoma in children, revealed that the immune system's T cells may be just as critical to fighting tumor cells as the viral therapy injections themselves.
Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue.
St. Jude researchers show that rhabdomyosarcoma also originates from endothelial cells lining blood vessels.
The findings may also lead to drugs to prevent rhabdomyosarcoma in children with a genetic predisposition to the cancer, Hatley said.
The researchers also explored whether another key cancer - activating pathway, called KRAS, might trigger rhabdomyosarcoma.
This discovery may help explain why rhabdomyosarcomas tend to occur in the head and neck.
The different location of such rhabdomyosarcomas may depend, for example, on the cell of origin.»
His experiments revealed the cells that became rhabdomyosarcoma were not muscle cells, but were immature cells that would mature into cells lining the inner surface of blood vessels.
«Moody also forged how rhabdomyosarcoma is managed in kids, and not just radiation therapy but how radiation is intertwined with chemotherapy.
The study focused on embryonal rhabdomyosarcoma caused by mutations in the Sonic Hedgehog signaling pathway and used a mouse model developed in Hatley's laboratory.
A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.
CSHL is launching a highly targeted effort to combat a rare and deadly type of sarcoma called rhabdomyosarcoma...
But dogs treated for rhabdomyosarcoma normally have a long - term survival rate.
Pleomorphic rhabdomyosarcoma with pulmonary metastasis in a stranded Steller (northern) sea lion (Eumatopias jubatus).
This study offers the first evidence that rhabdomyosarcoma patients might benefit from drugs that harness the mechanism to kill cancer cells, including medications that are on the market or in development.
No RAS pathway mutations were found in alveolar rhabdomyosarcoma.
From these studies we hope to identify new pathways to target in rhabdomyosarcoma and new sarcoma models we have generated and our currently characterizing.
«Overall, survival for patients with recurrent rhabdomyosarcoma is just 17 percent, and until now nothing was known about how tumors evolve in response to therapy,» said corresponding author Michael Dyer, Ph.D., a member of the St. Jude Department of Developmental Neurobiology and a Howard Hughes Medical Institute Investigator.
«But it also suggested there are likely multiple cells of origin for rhabdomyosarcoma.
We had just gotten through a successful tax season when the unthinkable happened: The youngest of our three children, 4 - year - old Nicholas, was diagnosed with rhabdomyosarcoma, a cancer of the connective tissue.
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.
Hatley said understanding the cell of origin will bring badly needed insights to aid diagnosis and treatment of rhabdomyosarcoma.
The results support the hypothesis that alveolar rhabdomyosarcoma is driven by a single chromosomal rearrangement.
This analysis suggests that a rare subset of tumor cells harbor different genetic alterations and that those cells serve as the seeds for the recurrence of rhabdomyosarcoma.»
About 350 new cases of rhabdomyosarcoma are identified each year in the U.S., making it the most common soft tissue tumor in children.
The results followed next generation, whole genome sequencing of the tumor and normal genomes of 16 tumors from 13 rhabdomyosarcoma patients.
«A better understanding of the machinery of rhabdomyosarcoma could enable entirely new treatment approaches.
St. Jude Children's Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children.
Such studies will aid diagnosis and treatment of rhabdomyosarcoma.
Hatley, along with Rene Galindo, Eric Olson and in collaboration with Graff, determined these tumors were rhabdomyosarcoma.
The unexpected discovery that rhabdomyosarcoma is not really a muscle cancer may offer broader lessons for researchers seeking the cellular origin of cancers.
All seven institutions used IGRT for treatment of ependymoma (cancer of the tissue of the brain or spinal cord), abdominal and pelvic sarcoma, and rhabdomyosarcoma (cancer of the muscles attached to the bones).
At the Solid Tumor Oncology Program, part of C.S. Mott Children's Hospital at the University of Michigan, we provide comprehensive, multidisciplinary care for children with rhabdomyosarcoma.
If a rhabdomyosarcoma is the diagnosis, your doctor will stage the tumor, which determines if and how far the cancer has spread.
At the Children's Oncology Group, we work on the design and implementation of studies regarding Ewing's sarcoma, osteosarcoma, rhabdomyosarcoma, and other soft tissue sarcomas.
A rhabdomyosarcoma can occur in many places in the body, most commonly around the structures of the head and neck, within the urogenital tract, and in the arms or legs.