Sentences with phrase «specific transcription factors»

Host proteins, including specific transcription factors with binding sites near transcription start sites, are necessary for this specificity (32 - 33).

Under these culture conditions, which provide for stem cell maintenance and inhibition of differentiation, as stem cell marker expression begins to drop, cells switch on the expression of lineage specific transcription factors at the RNA level.

However, the breakthrough identification of specific transcription factors connected to EBV infections opens new lines of study that could accelerate efforts to find cures.

Steve's lab works on neural stem cell specific transcription factors, and his focus, like Simona's, is to strip out all the heterogeneity and focus on universal features common to all gliomas.

We isolated subpopulations of embryonic stem cells using surface markers, then examined their expression of pluripotency genes and lineage specific transcription factors at the single cell level, and tested their ability to regenerate colonies of stem cells.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

Sequence - specific transcription factors contribute to latency by recruiting HDACs and other repressors to the virus promoter.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

Using chromatin accessibility and gene expression measurements, we present clear evidence that lineage specific enhancer dynamics in hematopoiesis is the result of lineage specific transcription factor activity.

1) van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Identification and cloning of TCF - 1, a T cell - specific transcription factor containing a sequence - specific HMG box.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

Bivalent marking of loci encoding lineage specific transcription factors in ES cells is thought to prepare these genes for rapid activation of transcription once the pluripotency network is extinguished [4].

The pluripotent population is characterized by a high degree of plasticity in chromatin structure [3], and lineage specific transcription factors show bivalent chromatin epigenetic marks characteristic of both suppression and inactivation [4].

Furthermore, IPA allows testing for significant enrichment of targets of specific transcription factors.

In early work, he identified a key molecule, T cell - specific transcription factor 1 (TCF - 1), that signals the immune cells known as T lymphocytes to proliferate.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.

Prior to the study, the broad effects of the thyroid - specific transcription factor, called FOXE1, on transcription levels of genes were not well characterized.

The activity of each gene then was analyzed in an attempt to find the specific transcription factor responsible for regulating the conversion of sugar to starch in the above - ground portions of the plant, primarily the grains.

One approach builds on the so - called zinc finger protein fold first described in sequence - specific transcription factors.

The team then asked this minimal model set to predict whether knockdown of a specific transcription factor would maintain the stem cell state or prompt differentiation.

CHiP - Seq data show that cell - type - specific promoters are enriched for cell - type - specific transcription factors.

A second project focuses on sequence - specific transcription factors that are recurrently mutated in breast cancer, such as FOXA1, GATA3, and TBX3.

The authors applied CHiP - Seq with 119 different DNA - binding proteins (including 87 sequence - specific transcription factors) to 72 cell types, finding:

Activated p53, a sequence - specific transcription factor, has been reported to bind to the p53RE on p53 - targeted genes such as p21, to direct its downstream signals and actions [43].

Testosterone is an androgenic steroid that binds to the androgen receptor (AR), a sequence - specific transcription factor.

Testosterone increases myogenin expression (a muscle - specific transcription factor for the development of functional skeletal muscle)