Sentences with phrase «subset of cells»

In a second paper, also published online today in Nature, developmental biologist Luis Parada and his colleagues at the University of Texas Southwestern Medical Center (UTSMC) in Dallas show that in mice that develop glioma, a form of brain cancer, tumor growth seems to come from a small subset of cells in the tumor.

Second, the AAV preps generally used for gene editing are low titre, and are therefore able to infect only a small subset of the cells used in a given experiment.

There it correlates with gene repression, but likely only in distinct subsets of cells within each organ, (see Schultz et al., 2015).

Rather, each tumor contains a small subset of cells with stem cell - like capacities that are responsible for initiating and sustaining tumor growth, while the bulk of the tumor cells lacks this ability.

«Narrow subset of cells is responsible for metastasis in multiple myeloma, study finds.»

«The findings are important because they show that the tumor microenvironment itself, and in particular a specific subset of cells in the tumor, is preventing T cells from trafficking to the tumor and mounting a response,» Stromnes said.

The approach was applied to better understand the variable responses of the aggressive brain tumor glioblastoma to a proposed therapeutic agent, revealing subsets of cells with reduced responsiveness to the treatment.

The brain's specialized subset of cells that take part in the inflammatory response is known as microglia.

Recent evidence suggests hemangiosarcoma conforms to the «cancer stem cell» model, where a defined subset of cells is responsible for initiating and maintaining the tumor.

Could Cas9 - DOG be developed soon to allow genome modification only in a small subset of cells?

M. J. Bertram et al., Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor - like genes.

Cancer stem cells are a subset of cells within tumors that are believed to be responsible for the initiation of cancer.

Research from past studies found that most tumor cells remain in the primary breast site, but a subset of cells leaves the breast and enters the bloodstream.

Doug Losordo of Tufts University is heading clinical trials in Massachusetts, Minnesota, and California to test a subset of the cells Perin uses.

Although earlier work assumed that all plant cells were equally labile, recent evidence suggests that only a subset of cells can transform into embryos.

Biophysicists led by Professor Erwin Frey, who holds the Chair of Biological and Statistical Physics at LMU, have now shown theoretically how this can be accomplished even when only a subset of cells actually emits the requisite signals.

The team found a subset of cells that distinguish between what the patients thought to be happy and fearful faces, even when they perceived ambiguous facial expressions incorrectly.

Frey and his colleagues made use of mathematical models to analyze the complex interplay between ecological factors and population dynamics, and were able to demonstrate that populations can indeed respond in a coordinated fashion to chemical information even when the signal molecules are generated by only a subset of the cells.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

Next, Wesson and Wilson repeated the experiment, this time presenting a subset of the cells with only a tone: 19 percent fired.

Often, the drivers of the collective population behavior are only a subset of cells.

For example, Roein - Peikar explained, metastasis (a way in which tumors spread and one of the most damaging characteristics of cancer) is often decided by the actions of a subset of cells within a tumor population.

One reason for this, explains Hai - Hui (Howard) Xue, MD, PhD, UI professor of microbiology and immunology, is that there are two kinds of tumor cells — bulk leukemia cells that can be killed by TKI drugs, and a subset of cells called leukemia stem cells, which are resistant to TKIs and to chemotherapy.

Now, the Martin team has found a subset of cells, squeezed in between the main LGN layers in marmoset monkeys that fire in response to inputs from both eyes.

Many dependencies were cancer - specific, in that silencing them each affected only a subset of the cell lines.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated.

Lin and Artandi wondered whether they could use telomerase expression as a marker to identify the subset of cells responsible for regenerating the liver during normal turnover.

In mice expressing GFP under the control of the 5 - HT3A promoter, a subset of cells in the geniculate ganglion and nerve fibers in taste buds are GFP - positive.

After 15 days, a subset of cells expressed regulators of RGC differentiation (Atoh7, Brn3b, and Islet1), while a smaller subset co-expressed Brn3b and the mature RGC marker Thy1, thus confirming a RGC identity.

Notably, only a subset of cells is strongly immunopositive for albumin in the enhanced hiPS - HEP cells and in hphep cultures, in agreement with the metabolic zonation [7] observed in liver slices (below).

Notably, only a subset of cells is strongly immunopositive for albumin in enhanced hiPS - HEP cells and in hphep cultures, in agreement with the metabolic zonation (Jungermann and Kietzmann 2000) observed in liver slices (Figure 3, Panel A).

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

- DOG be developed soon to allow genome modification only in a small subset of cells?

In mouse ES cultures, a subset of cells is positive for both Oct - 4 and the transcription factor Rex1 and these cell types can interconvert [10].

Mosaic Work - Around: CRISPR injected after fertilization operates after the first division and results in a subset of cells being fixed.

Instead, a very small number of neurons specifically activated by learning show an expansion of structure that's both surprisingly extensive — there's a dramatic increase in the size and complexity of the affected neurons — and yet highly restricted to a small subset of cells.