Sentences with phrase «translation initiation»

We also show that a general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2 at serine 51 (P - eIF2α), is required to maintain the quiescent state.

My Royal Society Travelling Fellowship took us to Basel, Switzerland, for me to study the signalling pathways involved in the phosphorylation of translation initiation factors.

The team confirmed that guanabenz acts by temporarily blocking the reactivation of a protein known as eukaryotic translation initiation factor 2 (eIF2α).

The Initiation Codon Determines the Efficiency but Not the Site of Translation Initiation in Chlamydomonas Chloroplasts

Ilona Kats is a graduate student in the Neuroscience program interested in the mechanism of cap - dependent translation initiation in autism and synaptic plasticity.

Norton, L. Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise.

Translation initiation site of Gag polyprotein is indicated.

The team determined that Dengue virus does not block the two known pathways that suppress translation initiation for cellular RNAs, but how this occurs is still a mystery.

Interest in studying tRNA fragments has been increasing swiftly as studies have shown that the fragments have regulatory roles and implicated individual fragments in cellular processes such as translation initiation, response to viral infection, response to DNA damage, etc..

We have developed several new mouse lines in which translation initiation can be inhibited in an inducible and conditional manner.

EF - P facilitates the proper positioning of the fMet - tRNAifMet for the formation of the first peptide bond during translation initiation.

Our laboratory has spent many years delineating the regulation of translation initiation by the mTORC1 and ERK signaling cascades during LTP, LTD, and memory formation in the hippocampus.

HMB stimulates protein synthesis in muscle by multiple mechanisms, including the mTOR / p70S6k pathway, which stimulates translation initiation of protein synthesis.

Briefly, a cascade of intracellular signaling events influenced by energy status, growth factors, and nutrient availability regulate muscle protein synthesis by modifying mRNA translation initiation and elongation (18, 30).

In the mice with prion disease, Mallucci disrupted this process by neutralising the gene — called eukaryotic translation initiation factor, or eIF2alpha - P — that halts protein production.

Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C. (2017) Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap - Dependent Translation Initiation.

mTORC1 is the central component of the insulin - signaling cascade [insulin / insulin - like growth factor (IGF)-- phosphatidylinositol 3 - kinase (PI3K) pathway)(Fig. 1) that regulates protein synthesis and mRNA translation through 2 primary mechanisms: 1) inactivation of the repressor of mRNA translation, eukaryotic translation initiation factor 4E - binding protein 1 (eIF4E - BP1), and 2) the activation of 70 - kDa ribosomal protein S6 kinase.

Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise.

Prodigal: prokaryotic gene recognition and translation initiation site identification — Dough Hyatt — March 2010

Inhibition of protein synthesis is thought to occur at the step of translation initiation.

Called eukaryotic translation initiation factor, or eIF2alpha - P, the gene generates a protein that needs to have a chemical grouping called a phosphate group attached to it to halt the protein production line.

This includes how subtle changes in gene sequences can impact the expression of encoded proteins through mechanisms including codon bias, mRNA stability, and translation initiation.

It has been reported that the yeast homologue of DDX3, Ded1, is essential for translation initiation (6), and DDX3 is able to rescue Ded1 - deficient yeast mutants (4).

Finally, the protein kinase PERK signals translational attenuation through phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2a) on serine residue 51.

The translation initiation factor, eIF4E, is an indirect target of mTOR because it is released by phosphorylation of its repressor 4E - BP1 by mTOR - raptor complex, thereby stimulating cap - dependent translation (7, 11, 12).

For example, previous studies have shown that eukaryotic translation initiation factor (eIF4E) and cyclic AMP responsive element B (CREB) are known to be activated by radiation [37 - 40].

For example, EIF4G3 encodes a eukaryotic translation initiation factor, and mutations in this gene have been shown to cause male limited infertility in mice by inducing meiosis and spermatogenesis arrest in meiotic prophase [58].

In vivo evidence for the prokaryotic model of extended codon - anticodon interaction in translation initiation

Leucine supplementation of a low - protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR - dependent translation initiation