Sentences with phrase «tumor rejection»
"Tumor rejection" refers to the body's natural defense mechanism to recognize and eliminate cancer cells. It means that the immune system recognizes the tumor as a threat and fights against it, preventing the tumor from growing or spreading. Full definition
Dr. Sharma is a trained medical oncologist and immunologist whose research work is focused on investigating mechanisms and pathways within the immune system that are responsible for tumor rejection and clinical benefit.
sciencemag.org
Hotspots of KRAS mutations are found in different tumor types and can serve as tumor rejection epitopes.
The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit improved tumor control relative to DGKζ − / − mice.
«Although both anti-CTLA-4 and anti-PD-1 improved tumor rejection, mice treated with anti-CTLA-4 exhibited superior tumor control, suggesting the memory T - cell response by this agent is more durable,» said Allison.
Pramod Srivastava and Lloyd J. Old identify the human homologue of the mouse tumor rejection antigen gp96.
They note that anti-CD47-mediated tumor rejection «requires both innate and adaptive immune responses.»
IDO1 has been implicated in immune modulation through its ability to limit T cell function and engage mechanisms of immune tolerance, and as such preventing tumor rejection.
«Tumor rejection requires both innate and adaptive immune responses against tumor cells.
This did induce an immune response but only led to tumor rejection in one - quarter of the animals.»
They normalized blood vessels in the tumor, thus additionally contributing to tumor rejection.
He proposed that blocking CLTA - 4 could enhance anti-tumor immune responses and conducted the first preclinical experiments showing that CTLA - 4 blockade could lead to tumor rejection.