Sentences with phrase «various cell types»

It should be straightforward to apply the new library for use in various cell types and in live mice.

For that to happen, a complex, only partially understood interplay takes place between various cell types in our skin.

For potential drugs to treat heart disease various cell types are used for the preliminary screening - but in the second round of testing, heart cells are necessary.

Moreover, the iPS cells can spontaneously differentiate or be induced into various cell types of three embryonic germ layers in vitro and in vivo when they are injected into immunodeficient mice for teratoma formation.

Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell - like state where they can continue to proliferate and can later differentiate into various cell types.

Associate Professor Rika Numano explained, «The W / O droplet electroporation technique has several advantages over conventional transfection techniques: small cell number required, as low as 1000 cells; small amount of DNA required, which makes it applicable for various cell types including neural cells; and changeable genome DNA.

Upon further analysis of these fetal muscle cells two new cell surface markers called ERBB3 and NGFR were discovered; this enabled the reserchers to precisely isolate muscle cells from human tissue and separate them from various cell types created using human pluripotent stem cells.

The ability of this gene to modify the other DM1 biomarkers will be explored in various cell types by classical experimental approaches and the molecular mechanism implicated to correct the DM1 missplicings will be analyzed.

However, no drug can cure infection so far, because various cell types continue to carry the virus in a latent, i.e. quiescent, state.

A healthy optic nerve has axons transmitting information from the eye to the brain along the nerve after considerable information processing and synaptic transmission between various cell types within the retina.

Named after the BMP signal protein, this pathway controls the evolution of various cell types depending on the protein concentration, similar to the Wnt pathway, but in a different direction.

But scientists are still piecing together the cues that trigger various cell types to form.

«Our subsequent examination of these artificial tissue samples revealed that various cell types characteristic of the midbrain had developed,» says Jens Schwamborn.

They also remained consistent across various cell types, except for a small subset that appeared to switch between promoter and enhancer states.

In suspension culture, they formed embryoid bodies (EBs), which contained various cell types originating from three embryonic germ layers.

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

This workshop will showcase a range of real - time, live - cell assays for various cell types and co-culture models, and will introduce brand new reagents and software tools that will enable you to perform live - cell immunocytochemistry and immunophenotyping.

«This includes the cell division, cell growth and the differentiation into various cell types, such as shoots, leaves or fruit.

In another novel finding, the team demonstrated that ANG achieves these dual functions by inducing RNA processing that is different in various cell types.

In addition, in collaboration with the Harvard Medical School bioinformatics team, he discovered (4) how global parameters of the transcriptome differ between various cell types.

The diversity of the various cell types displaying circadian clock activity suggests that for many tissues correct timing is important enough to warrant keeping track of it locally.

One likely reason for this is that animals undergo cellular differentiation; human life begins as a single cell that differentiates into the various cell types needed for different organs, body parts, blood, the immune system, etc..

Split Pool Ligation - based Transcriptome sequencing (SPLiT - seq) is a scalable technique for characterizing RNA in individual cells that can be used to identify the various cell types found in the brain and other tissues.

Long - term exposure of various cell types to beta - adrenergic agonists such as isoproterenol leads to an attenuated responsiveness («desensitization») of the adenylate cyclase system to further challenge with these agonists.

Much adult stem cell research focuses on identifying the genes and molecules that define such cells and allow them to replenish themselves indefinitely as they produce the various cell types of their organs — the defining characteristics of a stem cell.

This process, called cell differentiation, gives rise to all the various cell types, such as nerve, muscle, or blood cells, which are diverse in shape and function and make up tissues and organs.

For Nathans and Ecker, the first application of the technology was to map out epigenetic modifications in various cell types.

While the potential of adult stem cells has been understood for some time, researchers have argued that the pluripotency of embryonic stem cells — their ability to be transformed into most if not all of the various cell types of the body — make them more valuable both for research and potentially someday for treatment.

Once implanted, the cells are designed to differentiate into the various cell types that make up the pancreatic islet, which could allow for production of insulin and other hormones, such as glucagon, needed to control blood sugar levels.

«We are also trying to optimize this system and adapt it to various cell types, to ultimately create a versatile nanocomplex for use in a host of basic biology studies and chemical screening in regenerative medicine,» says team member Zhongliang Wang, who works in China and the US.

Various cell types in the vicinity of stem cells communicate with each other to correctly drive regeneration.

In the embryo, there are stem cells that are capable of becoming all of the various cell types of the human body.

Recently, Rothman and Südhof described the role of the Rab proteins and the SM (Sec1 / Munc18 - like) proteins in providing additional specificity and control to the process of SNARE scaffold assembly and vesicle docking to membranes in various cell types, thus confirming the general importance of these proteins (Science, vol 323, 23 January 2009).

Cellular biology: Isolation and culture of various cell types; cryopreservation; Mixed Lymphocyte Reaction (MLR); cloning by limiting dilution; cytotoxicity assays using Chromium - 51 release; proliferation assay (CFSE and 3H - thymidine); ELISA; Elispot; magnetic beads separation.

The marrow is extremely densely populated by various cell types (not just HSCs), so that the oxygen concentration drops steeply just microns away from feeding capillaries.

Various cell types have been examined for use in RPE cell replacement including immortalized cell lines, such as the human RPE cell line, ARPE19 [2], sheets of adult RPE [3], foetal RPE [4], RPE derived from human embryonic stem cells (HESC - RPE)[5]--[10] and many non-RPE cells lines [11]--[15].

Researching the role of long non-coding RNAs in various cell types that contribute to allergic asthma.

The CBC provides details about the number, size and shape of the various cells types, and identifies the presence of abnormal cells in circulation.

The CBC provides details about the number, size, and shape of the various cells types, as well as any abnormalities that may be present.