Sentences with word «vascularized»

The highly vascularized tissue had previously been observed in Ophiacodon, but its presence had been written off to ecological factors, like its aquatic lifestyle, rather than to its fundamental physiology.

A team at the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells.

«This research will help to establish the fundamental scientific understanding required for bioprinting of vascularized living tissues,» Zhijian Pei, National Science Foundation Program Director for the Directorate for Engineering Division of Civil, Mechanical and Manufacturing Innovation, which funded the project.

«I think the bigger picture here is in vascularized solids, ones that are kind of like tissues with vascular networks.

Consequently, poorly vascularized solid tumors and CNS metastases can not be effectively treated by intravenously - injected antibodies.

Tissue engineers have tried for years to produce lab - grown vascularized human tissues robust enough to serve as replacements for damaged human tissue.

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

Confocal microscopy image showing a cross-section of a 3D - printed, 1 - centimeter - thick vascularized tissue construct showing stem cell differentiation towards development of bone cells, following one month of active perfusion of fluids, nutrients, and cell growth factors.

In September, George Church of Harvard Medical School — it was he who delayed trying to give brain organoids a blood supply — told a small meeting that his lab had vascularized brain organoids.

She did her PhD research under the mentorship of Dr. William Baldwin at the Lerner Research Institute, where she studied the role of platelets and the complement system in vascularized organ transplant rejection.

But I suppose a lot of cancers do exactly that: create vascularized fast growing tissues.

Others are working with free - form fabrication technology to build fully vascularized tissues that might eventually lead to off - the - shelf transplants.

They are also using these elastic natural hydrogels for the regeneration of other tissues such as blood vessels, skeletal muscle, heart valves and vascularized skin.

These different mechanisms all allowed for the process of self - assembly of vascularized liver organ buds involving spatial rearrangements via self - organization.

Tissue engineered prefabricated vascularized flaps.

HB did not elicit a negative immune response, became vascularized, quickly integrated with surrounding tissues, and rapidly ossified and supported new bone growth without the need for added biological factors.

Researchers from the laboratories of Hiroshi Y. Yoshikawa and Hideki Taniguchi had previously demonstrated the in vitro formation of a 3D transplantable liver «organ bud» from human induced pluripotent stem cells (iPSCs) co-cultured with mesenchymal and endothelial progenitors, and allows for the growth of a small vascularized and functional organ [1 - 3].

Now, in a new study in Cell Stem Cell, the group have begun to delineate the mechanisms controlling organ bud formation, and from these findings they have been able to describe a general methodology for the formation of large vascularized, complex organ buds from diverse organs using specific stem cell combinations [4].

Hyaluronan - based heparin - incorporated hydrogels for generation of axially vascularized bioartificial bone tissues: In vitro and in vivo evaluation in a PLDLLA - TCP - PCL - composite system.

Chairs: Elena Aikawa, Brigham and Women's Hospital / Harvard Medical School and Anjelica Gonzalez, Yale University Christopher Hughes, University of California, Irvine Vascularized and perfused micro-tissues in culture and their use in drug screening Ying Zheng, University of Washington Engineering organ - specific microvasculature

Furthermore, when the authors assessed the subcutaneous implantation of hDPSCs grown on CPD scaffolds, they discovered that PDGF - BB modified cells generated more dentin - like mineralized tissue surrounded by highly vascularized dental pulp - like connective tissue at 12 weeks when compared to unmodified hDPSCs.

«Their ability to build living 3D vascularized tissues from the bottom - up provides a potential way to form macroscale functional tissue replacements that can be surgically connected to the body's own blood vessels to provide immediate perfusion of these artificial tissues, and thus, greatly increase their likelihood of survival.

«The foreskin contains over 240 feet of nerves and over 1,000 nerve endings, as well as being a highly vascularized structure.»

At the Beth Israel Medical Center both surgeons transfer vascularized lymph nodes from an healthy area of the body to the area affected with lymphedema.

Furthermore, if an ovary contacts the abdominal wall, cells appear able to adhere and vascularize effectively creating a new, albeit small, ovary..

A. Mansour et al., «An in vivo model of functional and vascularized human brain organoids,» Nat Biotechnol, doi: 10.1038 / nbt.4127, 2018.

The penis, he reasoned, is highly vascularized, «like a great big sponge» of blood vessels.

This exciting new strategy promises a scalable and flexible strategy for the formation of vascularized and functional organ buds of a useful size, all via the condensation of specific cells from desired multiple cell / tissue types.

To test the chip's new capabilities, the team treated the vascularized Heart Chip with a known inflammatory stimulant that specifically disrupts endothelial barriers or a heart stimulant that acts directly on cardiomyocytes.

«Our mouths are highly vascularized, including the tongue — that's why we take our temperatures there.

The entire face is highly vascularized and innervated, Freyberg says.

A vascularized super-thin silicone - rubber layer stretched over a window is transparent but enables efficient heat transfer, resulting in a cooler interior.

In case of cancer, the tumour must therefore recruit these monocytes to vascularize.

Generation of a vascularized and functional human liver from an iPSC - derived organ bud transplant.

While discussing preliminary clinical trial results, Dr. Laikind told Xconomy that «Three months after implantation, the cells are surviving, they are proliferating... the device is vascularized, and they are differentiating.»

Review of «Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell - Driven Condensation» from Cell Stem Cell by Stuart P. Atkinson

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell - Driven Condensation.

The trophosome is highly vascularized and contains specialized cells packed full of chemoautotrophic sulfur bacteria.

For the first time, researchers describe the formation of entirely hPSC - derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation

«3D Microfluidic Models of the Vascularized Tumor Microenvironment: Advancing Precision Medicine and Understanding Collective Migration»

However, researchers from the laboratory of Nenad Bursac (Duke University, Durham, NC, USA) have recently described the production and differentiation of induced myogenic progenitor cells (iMPCs) from hPSCs into the first entirely hPSC - derived 3D muscle tissues that survive, vascularize, and maintain function following transplantation [5].

If the cornea becomes diffusely pigmented, vascularized or scarred, visual impairment may be noted.

Dr. Brown removed the stones (subsequently found to be cystine stones) from Skye's bladder and prostate gland, neutered him to reduce the size of the prostate, repaired the prostate, and then used omentum, the vascularized fatty lining of the stomach, to repair the ruptured urethral wall.