Work currently being undertaken involves idiopathic epilepsy in Border Collies and hereditary cataract and progressive retinal atrophy in many breeds, including Siberian Huskies, Miniature Schnauzers and Tibetan Spaniels. (marcthevet.com)
«We don't know yet if the SMN lnc - RNA actually plays a role in the disease, but it is a convenient target that we've used to our advantage to treat spinal muscular atrophy in mice,» says Sumner. (sciencedaily.com)
Progression of disease results in significant muscle Atrophy of limbs and spinal musculature, hind limb weakness, a «bunny hopping» gait, and, in some cases, weakness in all four limbs resulting in an inability to walk. (pawprintgenetics.com)