Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue. (salk.edu)
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets. (massgenomics.org)
«HOXA5 protein acts as tumor suppressor in breast cancer, lab cell study shows.» (sciencedaily.com)