Sentences with word «ankyrin»

There are also many other differences in the number or coding sequences of ankyrin repeat genes between wMel strain genomes and wAu [21], [49](see also [15] and [48] for sequence of wMelCS).

This early work was followed by postdoctoral studies at Duke University, where he identified a novel and conserved role for the membrane skeletal protein ankyrin in post-Golgi delivery of membrane proteins to the plasma membrane in epithelial cells and photoreceptors.

The active ingredient comprises several DARPins (designed ankyrin repeat proteins).

I became an eye researcher completely by accident while trying to unravel the role of a protein called Ankyrin in forming biological important membrane domains in cells, in this case, the photoreceptor.

Because the gene for Ankyrin - G has popped up in several genome - wide association studies combing human DNA for genetic risk factors of bipolar disorder, the researchers focused their attention on its role in the brain.

Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat - encoding genes associated with a prophage region, one of which is sex - specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue.

The membrane associated adaptor ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids in these cargos.

The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin - like repeats

Transient Receptor Potential Ankyrin 1 Ion Channel Facilitates Acute Inflammation Induced by Surgical Incision in Mice

In collaboration with Dr. Ke Xu's lab at UC Berkeley, the team determined that this is because of aberrant accumulation and distribution of Ankyrin - G in the AIS.

The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the human erythrocyte protein ankyrin.

To this end, the team identified that Rbfox controls the splicing of the Ankyrin - G gene, which encodes the so - called «interaction hub protein» in the AIS, and found that the change of splicing in a small segment in this gene renders it unable to perform its normal function in organizing the AIS.

Like ankyrins, tankyrase contains 24 ankyrin repeats in a domain responsible for its interaction with TRF1.

Remarkably, the activity levels of ankyrin - G mutant mice given the drugs returned to those of the controls.

To circumvent that problem, the researchers generated their new mouse so that ankyrin - G would only be lost in the pyramidal neurons found in the front of the brain (the region believed to be most relevant for psychiatric disorders) in adolescent and adult mice.

Ankyrin - G is normally found in pyramidal neurons in the brain of mammals, including people.

Their collaborators — Paul Jenkins, Ph.D., and Vann Bennett, M.D., Ph.D., then at Duke University Medical Center — had tried creating a mouse mutant completely lacking the ankyrin - G protein, but the mice didn't survive because ankyrin - G seems to be required for nervous system development.

In baseline tests, the high - energy ankyrin - G mice usually swam longer, only floating for about 10 seconds of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.

The research group hopes to use its ankyrin - G mice to better understand the biology of bipolar disorder, to help clarify how lithium works to treat bipolar disorder, and to test new treatments for bipolar disorder.

Tankyrase, a protein with homology to ankyrins and to the catalytic domain of poly (adenosine diphosphate — ribose) polymerase (PARP), was identified and localized to human telomeres.

Normal mice tend to hug the walls and not venture out into open space, but the ankyrin - G mutant mice were more active and spent much more time in the open part of the space.

To see if the mutant mice developed depressive - like traits under those conditions, the researchers stressed the ankyrin - G mice by placing them with a bigger, «bully» mouse for daily sessions over two weeks.

The drug made the ankyrin - G mutant mice more hyperactive, indicating they did not have «mouse - ADHD.»

Specifically, the mice lacked the protein ankyrin - G, in particular neurons in the brain, a defect that appears to make the animals both hyperactive and less fearful, a behavioral profile suggestive of a mania - like state for a mouse.

To see if the loss of ankyrin - G in the pyramidal neurons changed the animals» behavior, the researchers used tests including a so - called «open field» test to see how the mice acted when placed in an empty chamber.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.